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Chemical Compound Review

ribitol     pentane-1,2,3,4,5-pentol

Synonyms: Pentitol, Adonite, Adonit, Ribito, Xylite, ...
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Disease relevance of ribitol


High impact information on ribitol


Chemical compound and disease context of ribitol


Biological context of ribitol


Anatomical context of ribitol


Associations of ribitol with other chemical compounds


Gene context of ribitol

  • Dose-dependent competitive inhibition by ribitol teichoic acid was linear and equivalent for MRSA and MSSA (r, .949, P less than .001) [21].
  • The new enzyme was termed ARD1p (D-arabitol dehydrogenase 1) [29].
  • The predicted protein products of nodF and nodG show homology with acyl carrier protein and ribitol dehydrogenase, respectively [30].
  • The genes of the ribitol and D-arabitol operons are very closely linked and lie in a mirror image arrangement, rtlB-rtlA-rtlC-atlC-atlA-atlB, between metG and his on the E. coli chromosome [31].
  • Rhodopsin kinase has been difficult to store with retention of activity, but can be successfully stored frozen at -20 degrees C in 20% adonitol [32].

Analytical, diagnostic and therapeutic context of ribitol


  1. Candidiasis: detection by gas-liquid chromatography of D-arabinitol, a fungal metabolite, in human serum. Kiehn, T.E., Bernard, E.M., Gold, J.W., Armstrong, D. Science (1979) [Pubmed]
  2. Polyol profiles in Down syndrome. myo-Inositol, specifically, is elevated in the cerebrospinal fluid. Shetty, H.U., Schapiro, M.B., Holloway, H.W., Rapoport, S.I. J. Clin. Invest. (1995) [Pubmed]
  3. Structure of wild-type and mutant repressors and of the control region of the rbt operon of Klebsiella aerogenes. Wu, J., Anderton-Loviny, T., Smith, C.A., Hartley, B.S. EMBO J. (1985) [Pubmed]
  4. Structure of linkage region between ribitol teichoic acid and peptidoglycan in cell walls of Staphylococcus aureus H. Kojima, N., Araki, Y., Ito, E. J. Biol. Chem. (1983) [Pubmed]
  5. Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase. Agarwal, A.K., Monder, C., Eckstein, B., White, P.C. J. Biol. Chem. (1989) [Pubmed]
  6. Independent signaling pathways regulate cellular turgor during hyperosmotic stress and appressorium-mediated plant infection by Magnaporthe grisea. Dixon, K.P., Xu, J.R., Smirnoff, N., Talbot, N.J. Plant Cell (1999) [Pubmed]
  7. Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy. Huck, J.H., Verhoeven, N.M., Struys, E.A., Salomons, G.S., Jakobs, C., van der Knaap, M.S. Am. J. Hum. Genet. (2004) [Pubmed]
  8. Nonculture methods for diagnosis of disseminated candidiasis. Reiss, E., Morrison, C.J. Clin. Microbiol. Rev. (1993) [Pubmed]
  9. Alcohol and polyol dehydrogenases are both divided into two protein types, and structural properties cross-relate the different enzyme activities within each type. Jörnvall, H., Persson, M., Jeffery, J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  10. Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti. Baker, M.E. Mol. Endocrinol. (1989) [Pubmed]
  11. Response to a Haemophilus influenzae type b diphtheria CRM197 conjugate vaccine in children with a defect of antibody production to Haemophilus influenzae type b polysaccharide. Schneider, L.C., Insel, R.A., Howie, G., Madore, D.V., Geha, R.S. J. Allergy Clin. Immunol. (1990) [Pubmed]
  12. Purification and properties of Klebsiella aerogenes D-arabitol dehydrogenase. Neuberger, M.S., Patterson, R.A., Hartley, B.S. Biochem. J. (1979) [Pubmed]
  13. Serum arabinitol concentrations and arabinitol/creatinine ratios in invasive candidiasis. Gold, J.W., Wong, B., Bernard, E.M., Kiehn, T.E., Armstrong, D. J. Infect. Dis. (1983) [Pubmed]
  14. The arabinitol appearance rate in laboratory animals and humans: estimation from the arabinitol/creatine ratio and relevance to the diagnosis of candidiasis. Wong, B., Bernard, E.M., Gold, J.W., Fong, D., Armstrong, D. J. Infect. Dis. (1982) [Pubmed]
  15. Protection against heat-induced cell killing by polyols in vitro. Henle, K.J., Peck, J.W., Higashikubo, R. Cancer Res. (1983) [Pubmed]
  16. Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon. Yamada, M., Saier, M.H. J. Biol. Chem. (1987) [Pubmed]
  17. The orientation of substrate and reaction intermediates in the active site of ribulose-1,5-bisphosphate carboxylase. Lorimer, G.H., Gutteridge, S., Reddy, G.S. J. Biol. Chem. (1989) [Pubmed]
  18. Inositol 1,2,3-trisphosphate and inositol 1,2- and/or 2,3-bisphosphate are normal constituents of mammalian cells. Barker, C.J., French, P.J., Moore, A.J., Nilsson, T., Berggren, P.O., Bunce, C.M., Kirk, C.J., Michell, R.H. Biochem. J. (1995) [Pubmed]
  19. Ocular immunity to Staphylococcus aureus. Mondino, B.J., Laheji, A.K., Adamu, S.A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  20. Corneal antibody levels to ribitol teichoic acid in rabbits immunized with staphylococcal antigens using various routes. Mondino, B.J., Brawman-Mintzer, O., Adamu, S.A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  21. Comparison of in vitro adherence of methicillin-sensitive and methicillin-resistant Staphylococcus aureus to human nasal epithelial cells. Ward, T.T. J. Infect. Dis. (1992) [Pubmed]
  22. Effects of polyhydric and monohydric compounds on the stability of type I receptors for adrenal steroids in brain cytosol. Emadian, S.M., Luttge, W.G. J. Neurochem. (1988) [Pubmed]
  23. Synthesis of teichoic acid by Bacillus subtilis protoplasts. Bertram, K.C., Hancock, I.C., Baddiley, J. J. Bacteriol. (1981) [Pubmed]
  24. L-Arabinosuria: a new defect in human pentose metabolism. Onkenhout, W., Groener, J.E., Verhoeven, N.M., Yin, C., Laan, L.A. Mol. Genet. Metab. (2002) [Pubmed]
  25. Serological studies on chemostat-grown cultures of Lactobacillus fermentum and Lactobacillus plantarum. Knox, K.W., Campbell, L.K., Broady, K.W., Wicken, A.J. Infect. Immun. (1979) [Pubmed]
  26. Effects of gastrointestinal candidiasis, antibiotics, dietary arabinitol, and cortisone acetate on levels of the Candida metabolite D-arabinitol in rat serum and urine. Wong, B., Brauer, K.L., Clemens, J.R., Beggs, S. Infect. Immun. (1990) [Pubmed]
  27. Relationship of the cell wall composition of group H streptococci and Streptococcus sanguis to their serological properties. Rosan, B. Infect. Immun. (1976) [Pubmed]
  28. Role of D-ribose as a cometabolite in D-xylose metabolism by Saccharomyces cerevisiae. van Zyl, C., Prior, B.A., Kilian, S.G., Brandt, E.V. Appl. Environ. Microbiol. (1993) [Pubmed]
  29. Characterization of a novel NADP(+)-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae. Link, T., Lohaus, G., Heiser, I., Mendgen, K., Hahn, M., Voegele, R.T. Biochem. J. (2005) [Pubmed]
  30. Nucleotide sequence of Rhizobium meliloti RCR2011 genes involved in host specificity of nodulation. Debellé, F., Sharma, S.B. Nucleic Acids Res. (1986) [Pubmed]
  31. Ribitol and D-arabitol catabolism in Escherichia coli. Scangos, G.A., Reiner, A.M. J. Bacteriol. (1978) [Pubmed]
  32. Purification and characterization of rhodopsin kinase. Palczewski, K., McDowell, J.H., Hargrave, P.A. J. Biol. Chem. (1988) [Pubmed]
  33. Comparison of antibody, antigen, and metabolite assays in rat models of systemic and gastrointestinal candidiasis. Greenfield, R.A., Troutt, D.L., Rickard, R.C., Altmiller, D.H. J. Clin. Microbiol. (1988) [Pubmed]
  34. Diagnosis of invasive candidiasis in neutropenic children with cancer by determination of D-arabinitol/L-arabinitol ratios in urine. Christensson, B., Wiebe, T., Pehrson, C., Larsson, L. J. Clin. Microbiol. (1997) [Pubmed]
  35. Evaluation of serum arabinitol as a diagnostic test for candidiasis. Wells, C.L., Sirany, M.S., Blazevic, D.J. J. Clin. Microbiol. (1983) [Pubmed]
  36. Effect of the rehydration medium on the recovery of freeze-dried lactic acid bacteria. de Valdez, G.F., de Giori, G.S., de Ruiz Holgado, A.P., Oliver, G. Appl. Environ. Microbiol. (1985) [Pubmed]
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