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Gene Review:

STR2 - Str2p

Saccharomyces cerevisiae S288c

Synonyms: Cystathionine gamma-synthase, J2063, O-succinylhomoserine (thiol)-lyase, Sulfur transfer protein 2, YJR130C

Hansen, J. et al., Yamagata, S. et al., Nagasawa, T. et al., Seiflein, T.A. et al.

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Disease relevance of STR2

In the enteric bacteria Escherichia coli and Salmonella enterica, these reactions are catalyzed by irreversible cystathionine-gamma-synthase and cystathionine-beta-lyase enzymes [1].

High impact information on STR2

Cystathionine beta-synthase (EC 4.2.1.22) and cystathionine gamma-synthase (EC 4.2.99.9) activities were also detected in crude extracts of S. phaeochromogenes, but cystathionine beta-lyase (EC 4.4.1.8) was not [2].
Cystathionine gamma-lyase of Saccharomyces cerevisiae was immobilized to aminohexyl-Sepharose through the cofactor pyridoxal 5'-phosphate and was characterized with respect to its cystathionine gamma-synthase activity [3].

Biological context of STR2

Two genes that presumably encode cystathionine gamma-synthase and cystathionine beta-lyase were identified by genetic disruption (ORFs YJR130c and YGL184c), yielding yeast strains that cannot convert cysteine into homocysteine [4].

References

Two transsulfurylation pathways in Klebsiella pneumoniae. Seiflein, T.A., Lawrence, J.G. J. Bacteriol. (2006) [Pubmed]
Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization. Nagasawa, T., Kanzaki, H., Yamada, H. J. Biol. Chem. (1984) [Pubmed]
Immobilization of Saccharomyces cerevisiae cystathionine gamma-lyase and application of the product to cystathionine synthesis. Yamagata, S., Akamatsu, T., Iwama, T. Appl. Environ. Microbiol. (2004) [Pubmed]
Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Hansen, J., Johannesen, P.F. Mol. Gen. Genet. (2000) [Pubmed]

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AGOS_AER164C	Ashbya gossypii ATCC 10895
KLLA0B04378g	Kluyveromyces lactis NRRL Y-1140
MGG_03583	Magnaporthe oryzae 70-15
NCU02430	Neurospora crassa OR74A
SPBC15D4.09c	Schizosaccharomyces pombe 972h-

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