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Gene Review

CYS3  -  cystathionine gamma-lyase CYS3

Saccharomyces cerevisiae S288c

Synonyms: CYI1, Cystathionine gamma-lyase, FUN35, Gamma-cystathionase, STR1, ...
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Disease relevance of CYS3


High impact information on CYS3


Biological context of CYS3

  • Genetic analysis indicates that CYS3 is a hotspot of meiotic gene conversion, with a putative 5'-3' polarity gradient of conversion frequencies [6].
  • By comparison of the deduced amino acid sequence with the N-terminal amino acid sequence of cystathionine gamma-lyase, CYS3 (CYI1) was concluded to be the structural gene for this enzyme [2].
  • Yeast cys3 and gsh1 mutant cells display overlapping but non-identical symptoms of oxidative stress with regard to subcellular protein localization and CDP-DAG metabolism [8].
  • The amino-acid substitutions of the CYS3 protein present in a temperature-sensitive cys-3 mutant and in a second-site revertant of a cys-3 null mutation are presented and are shown to affect their DNA-binding activities [9].
  • Surprisingly, an extended promoter region of the cys-3 gene in the Mauriceville strain and in N. intermedia was very well conserved with that of the standard N. crassa gene, including the presence of three CYS3-binding sites possibly involved in autogenous control [9].

Associations of CYS3 with chemical compounds


Other interactions of CYS3


Analytical, diagnostic and therapeutic context of CYS3


  1. Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization. Nagasawa, T., Kanzaki, H., Yamada, H. J. Biol. Chem. (1984) [Pubmed]
  2. Cloning and characterization of the CYS3 (CYI1) gene of Saccharomyces cerevisiae. Ono, B., Tanaka, K., Naito, K., Heike, C., Shinoda, S., Yamamoto, S., Ohmori, S., Oshima, T., Toh-e, A. J. Bacteriol. (1992) [Pubmed]
  3. The nucleotide mapping of DNA double-strand breaks at the CYS3 initiation site of meiotic recombination in Saccharomyces cerevisiae. de Massy, B., Rocco, V., Nicolas, A. EMBO J. (1995) [Pubmed]
  4. Changes in chromatin structure at recombination initiation sites during yeast meiosis. Ohta, K., Shibata, T., Nicolas, A. EMBO J. (1994) [Pubmed]
  5. Identification of the copper regulon in Saccharomyces cerevisiae by DNA microarrays. Gross, C., Kelleher, M., Iyer, V.R., Brown, P.O., Winge, D.R. J. Biol. Chem. (2000) [Pubmed]
  6. CYS3, a hotspot of meiotic recombination in Saccharomyces cerevisiae. Effects of heterozygosity and mismatch repair functions on gene conversion and recombination intermediates. Vedel, M., Nicolas, A. Genetics (1999) [Pubmed]
  7. Genetic analysis of a new mutation conferring cysteine auxotrophy in Saccharomyces cerevisiae: updating of the sulfur metabolism pathway. Cherest, H., Surdin-Kerjan, Y. Genetics (1992) [Pubmed]
  8. Yeast cys3 and gsh1 mutant cells display overlapping but non-identical symptoms of oxidative stress with regard to subcellular protein localization and CDP-DAG metabolism. Matiach, A., Schröder-Köhne, S. Mol. Genet. Genomics (2001) [Pubmed]
  9. Functional analysis of different regions of the positive-acting CYS3 regulatory protein of Neurospora crassa. Coulter, K.R., Marzluf, G.A. Curr. Genet. (1998) [Pubmed]
  10. Homocysteine accumulation causes a defect in purine biosynthesis: further characterization of Schizosaccharomyces pombe methionine auxotrophs. Fujita, Y., Ukena, E., Iefuji, H., Giga-Hama, Y., Takegawa, K. Microbiology (Reading, Engl.) (2006) [Pubmed]
  11. Cysteine biosynthesis in Saccharomyces cerevisiae occurs through the transsulfuration pathway which has been built up by enzyme recruitment. Cherest, H., Thomas, D., Surdin-Kerjan, Y. J. Bacteriol. (1993) [Pubmed]
  12. Cysteine biosynthesis in Saccharomyces cerevisiae: a new outlook on pathway and regulation. Ono, B.I., Hazu, T., Yoshida, S., Kawato, T., Shinoda, S., Brzvwczy, J., Paszewski, A. Yeast (1999) [Pubmed]
  13. Two transsulfurylation pathways in Klebsiella pneumoniae. Seiflein, T.A., Lawrence, J.G. J. Bacteriol. (2006) [Pubmed]
  14. Cloning and bacterial expression of the CYS3 gene encoding cystathionine gamma-lyase of Saccharomyces cerevisiae and the physicochemical and enzymatic properties of the protein. Yamagata, S., D'Andrea, R.J., Fujisaki, S., Isaji, M., Nakamura, K. J. Bacteriol. (1993) [Pubmed]
  15. Glutathione as an endogenous sulphur source in the yeast Saccharomyces cerevisiae. Elskens, M.T., Jaspers, C.J., Penninckx, M.J. J. Gen. Microbiol. (1991) [Pubmed]
  16. Immobilization of Saccharomyces cerevisiae cystathionine gamma-lyase and application of the product to cystathionine synthesis. Yamagata, S., Akamatsu, T., Iwama, T. Appl. Environ. Microbiol. (2004) [Pubmed]
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