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Gene Review

ERV1  -  Erv1p

Saccharomyces cerevisiae S288c

Synonyms: 14 kDa regulatory protein, Essential for respiration and vegetative growth protein 1, Mitochondrial FAD-linked sulfhydryl oxidase ERV1, YGR029W
 
 
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Disease relevance of ERV1

 

High impact information on ERV1

  • The new work clarifies the molecular function of Mia40 and reveals Mia40 to be the first physiological substrate for the FAD-linked Erv1 [2].
  • Mia40 contains cysteine residues, which are oxidized by the sulfhydryl oxidase Erv1 [3].
  • Expression of the ERV2 (essential for respiration and vegetative growth 2) gene from a high-copy plasmid cannot substitute for the lack of ERV1, suggesting that the two proteins perform nonredundant functions [4].
  • Here, we identify the essential Erv1p of Saccharomyces cerevisia mitochondria as a novel component that is specifically required for the maturation of Fe/S proteins in the cytosol, but not in mitochondria [5].
  • Both Erv1p and full-length ALR are located in the mitochondrial intermembrane space and represent the first components of this compartment with a role in the biogenesis of cytosolic Fe/S proteins [5].
 

Biological context of ERV1

 

Associations of ERV1 with chemical compounds

  • Members of the Quiescin-sulfhydryl oxidase (QSOX) family utilize a thioredoxin domain and a small FAD-binding domain homologous to the yeast ERV1p protein to oxidize sulfhydryl groups to disulfides with the reduction of oxygen to hydrogen peroxide [8].
 

Other interactions of ERV1

  • Depletion of Erv1 or conditions reducing Mia40 prevent protein import [3].

References

  1. An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine. Lewis, T., Zsak, L., Burrage, T.G., Lu, Z., Kutish, G.F., Neilan, J.G., Rock, D.L. J. Virol. (2000) [Pubmed]
  2. A disulfide relay system in mitochondria. Tokatlidis, K. Cell (2005) [Pubmed]
  3. A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Mesecke, N., Terziyska, N., Kozany, C., Baumann, F., Neupert, W., Hell, K., Herrmann, J.M. Cell (2005) [Pubmed]
  4. Yeast ERV2p is the first microsomal FAD-linked sulfhydryl oxidase of the Erv1p/Alrp protein family. Gerber, J., Mühlenhoff, U., Hofhaus, G., Lill, R., Lisowsky, T. J. Biol. Chem. (2001) [Pubmed]
  5. An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins. Lange, H., Lisowsky, T., Gerber, J., Mühlenhoff, U., Kispal, G., Lill, R. EMBO Rep. (2001) [Pubmed]
  6. ERV1 is involved in the cell-division cycle and the maintenance of mitochondrial genomes in Saccharomyces cerevisiae. Lisowsky, T. Curr. Genet. (1994) [Pubmed]
  7. Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c. Allen, S., Balabanidou, V., Sideris, D.P., Lisowsky, T., Tokatlidis, K. J. Mol. Biol. (2005) [Pubmed]
  8. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Thorpe, C., Hoober, K.L., Raje, S., Glynn, N.M., Burnside, J., Turi, G.K., Coppock, D.L. Arch. Biochem. Biophys. (2002) [Pubmed]
 
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