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Gene Review

MST1  -  threonine--tRNA ligase MST1

Saccharomyces cerevisiae S288c

Synonyms: ThrRS, Threonine--tRNA ligase, mitochondrial, Threonyl-tRNA synthetase, YKL194C
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Disease relevance of MST1


High impact information on MST1

  • Phosphorylation of serine 14 of histone H2B, catalyzed by Mst1 kinase, has been linked to chromatin compaction during apoptosis [3].
  • Antibodies to the fusion protein detect a 50-55-kDa protein in wild type yeast mitochondria but not in mitochondria of a strain in which the chromosomal MST1 gene was replaced by a copy of the same gene disrupted by insertion of the yeast LEU2 gene [1].
  • Amino-acylation of wild-type mitochondrial tRNAs with a mitochondrial extract from mst1 mutants fail to acylate tRNAThr1 (anticodon: 3'-GAU-5') but show normal acylation of tRNAThr2 (anticodon: 3'-UGU-5') [1].
  • In addition, among several mutations at the third base pair in the acceptor stem, only the G3-U70 mutant was a poor substrate for ThrRS, suggesting that the G3-U70 wobble pair, which is the identity determinant of tRNA(Ala), acts as a negative element for ThrRS [2].


  1. Characterization of a yeast nuclear gene (MST1) coding for the mitochondrial threonyl-tRNA1 synthetase. Pape, L.K., Koerner, T.J., Tzagoloff, A. J. Biol. Chem. (1985) [Pubmed]
  2. Identity elements of Thermus thermophilus tRNA(Thr). Nameki, N., Asahara, H., Hasegawa, T. FEBS Lett. (1996) [Pubmed]
  3. Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Ahn, S.H., Cheung, W.L., Hsu, J.Y., Diaz, R.L., Smith, M.M., Allis, C.D. Cell (2005) [Pubmed]
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