The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SMY1  -  Smy1p

Saccharomyces cerevisiae S288c

Synonyms: Kinesin-related protein SMY1, Suppressor protein SMY1, YKL079W, YKL409
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on SMY1


High impact information on SMY1

  • We have also observed a genetic interaction between SMY1 and two of the late SEC mutations, sec2 and sec4 [1].
  • Unexpectedly, we found that abolition of microtubules by nocodazole does not interfere with the ability of Smy1p to correct the mutant Myo2p defect, nor does it interfere with the ability of Smy1p to localize properly [1].
  • We have previously reported that a defect in Myo2p, a myosin in budding yeast (Saccharomyces cerevisiae), can be partially corrected by overexpression of Smy1p, which is by sequence a kinesin-related protein (Lillie, S.H., and S.S. Brown. 1992. Nature. 356:358- 361) [1].
  • Such a functional link between putative actin- and microtubule-based motors is surprising, so here we have tested the prediction that Smy1p indeed acts as a microtubule-based motor [1].
  • Smy1p, a kinesin-related protein that does not require microtubules [1].

Biological context of SMY1


Physical interactions of SMY1

  • We now show by two-hybrid analysis that a 69-amino acid region of the Smy1p tail interacts with the globular portion of the Myo2p tail [4].

Regulatory relationships of SMY1

  • We propose that Smy1p enhances some aspect of Myo2p function, perhaps delivery or docking of vesicles at the bud tip [4].

Other interactions of SMY1


Analytical, diagnostic and therapeutic context of SMY1


WikiGenes - Universities