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Gene Review

SEC2  -  Sec2p

Saccharomyces cerevisiae S288c

Synonyms: GDP-GTP exchange factor SEC2, N0641, Rab guanine nucleotide exchange factor SEC2, YNL272C
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High impact information on SEC2


Biological context of SEC2

  • All phenotypes of the temperature-sensitive sec2 alleles are partially suppressed by duplication of the SEC4 gene, but the lethality of a sec2 disruption is not suppressed [5].
  • In addition, we mapped the ERG24 gene to chromosome XIV between the MET2 and SEC2 genes [6].

Physical interactions of SEC2

  • We showed also that GYP5 genetically interacts with SEC2, which encodes the Sec4p exchange factor [7].

Regulatory relationships of SEC2

  • Moreover, at 34 degrees C, overexpression of Scd5p suppresses the temperature sensitivity of a sec2 mutant, which is blocked at a post-Golgi step of the secretory pathway [8].


  1. Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Rahl, P.B., Chen, C.Z., Collins, R.N. Mol. Cell (2005) [Pubmed]
  2. Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. Ortiz, D., Medkova, M., Walch-Solimena, C., Novick, P. J. Cell Biol. (2002) [Pubmed]
  3. The role of the COOH terminus of Sec2p in the transport of post-Golgi vesicles. Elkind, N.B., Walch-Solimena, C., Novick, P.J. J. Cell Biol. (2000) [Pubmed]
  4. Smy1p, a kinesin-related protein that does not require microtubules. Lillie, S.H., Brown, S.S. J. Cell Biol. (1998) [Pubmed]
  5. Sec2 protein contains a coiled-coil domain essential for vesicular transport and a dispensable carboxy terminal domain. Nair, J., Müller, H., Peterson, M., Novick, P. J. Cell Biol. (1990) [Pubmed]
  6. Aerobic isolation of an ERG24 null mutant of Saccharomyces cerevisiae. Crowley, J.H., Smith, S.J., Leak, F.W., Parks, L.W. J. Bacteriol. (1996) [Pubmed]
  7. Gyp5p and Gyl1p are involved in the control of polarized exocytosis in budding yeast. Chesneau, L., Dupré, S., Burdina, A., Roger, J., Le Panse, S., Jacquet, M., Cuif, M.H. J. Cell. Sci. (2004) [Pubmed]
  8. SCD5, a suppressor of clathrin deficiency, encodes a novel protein with a late secretory function in yeast. Nelson, K.K., Holmer, M., Lemmon, S.K. Mol. Biol. Cell (1996) [Pubmed]
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