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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

VPS24  -  ESCRT-III subunit protein VPS24

Saccharomyces cerevisiae S288c

Synonyms: DID3, DOA4-independent degradation protein 3, ESCRT-III complex subunit VPS24, VPL26, Vacuolar protein-sorting-associated protein 24, ...
 
 
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High impact information on VPS24

  • This protein is orthologous to the Saccharomyces cerevisiae protein, Vps24p, a class-E vacuolar protein-sorting protein [1].
  • Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization [1].
  • We hypothesize that accumulation of Vps24 on membranes occurs when membrane association (dependent on interaction of phosphatidylinositol 3,5-bisphosphate with the N-terminal domain of the protein) is uncoupled from membrane disassociation (driven by Vps4p) [1].
  • In contrast the human genome encodes 10 homologous proteins (CHMP1A (approved gene symbol PCOLN3), 1B, 2A, 2B, 3 (approved gene symbol VPS24), 4A, 4B, 4C, 5, and 6) [2].
  • Aovps24, a homologue of VPS24, is required for vacuolar formation which could maintain proper growth and development in the filamentous fungus Aspergillus oryzae [3].
 

Biological context of VPS24

References

  1. Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization. Whitley, P., Reaves, B.J., Hashimoto, M., Riley, A.M., Potter, B.V., Holman, G.D. J. Biol. Chem. (2003) [Pubmed]
  2. A systematic analysis of human CHMP protein interactions: Additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Tsang, H.T., Connell, J.W., Brown, S.E., Thompson, A., Reid, E., Sanderson, C.M. Genomics (2006) [Pubmed]
  3. Aovps24, a homologue of VPS24, is required for vacuolar formation which could maintain proper growth and development in the filamentous fungus Aspergillus oryzae. Tatsumi, A., Kikuma, T., Arioka, M., Kitamoto, K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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