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Gene Review

CHMP3  -  charged multivesicular body protein 3

Homo sapiens

Synonyms: CGI-149, CGI149, Charged multivesicular body protein 3, Chromatin-modifying protein 3, NEDF, ...
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Disease relevance of VPS24


Psychiatry related information on VPS24

  • HD patients had a higher frequency of arousals per hour (25.1 versus 17.1; P < 0.0001) and apnea-hypopneas per hour (27.2 versus 15.2; P < 0.0001) and greater percentage of the total sleep time below an oxygen saturation of 90% (7.2 versus 1.8; P < 0.0001) [5].
  • Women who developed dementia between ages 79 and 88 years were overweight, with a higher average BMI at age 70 years (27.7 vs 25.7; P =.007), 75 years (27.9 vs 25.0; P<.001), and 79 years (26.9 vs 25.1; P =.02) compared with nondemented women [6].
  • DESIGN: We determined EE(DLW), energy intake at weight maintenance, and EE from 7-d physical activity records (EE(Record)) and a 7-d physical activity recall questionnaire (EE(Recall)) in 24 men aged 41 plus minus 2.0 y ( plus minus SEM) with a body mass index (in kg/m(2)) of 25.1 plus minus 0 [7].
  • A first major cardiovascular event occurred in 242 candesartan patients and in 268 control patients; risk reduction with candesartan was 10.9% [95% confidence interval (CI), -6.0 to 25.1, P = 0.19] [8].
  • A total of 106 affective, 101 schizoaffective and 148 schizophrenic disorders were investigated after a long-term course of illness (mean follow-up period 25.1 years), employing narrow definitions and using reliable international instruments of evaluation [9].

High impact information on VPS24

  • Cumulative mortality was 28 percent for the 281 digoxin-treated patients as compared with 11 percent for the 622 patients who did not receive digoxin (P less than 0.001; follow-up interval, six days to 36 months; mean, 25.1 months) [10].
  • The main outcome was reduced by 25% with losartan compared with atenolol, 25.1 vs 35.4 events per 1000 patient-years (relative risk [RR], 0.75; 95% confidence interval [CI], 0.56-1.01; P =.06, adjusted for risk and degree of ECG-LVH; unadjusted RR, 0.71; 95% CI, 0.53-0.95; P =.02) [11].
  • SETTING--A teratology consultation program and two neurology services in Toronto, Ontario. RESULTS--Children exposed to phenytoin in utero had a mean (+/- SD) global IQ 10 points lower (95% confidence interval, 4.9 to 15.8 points) than their matched controls (113.4 +/- 13.1 and 103.1 +/- 25.1; P = .038) [12].
  • Compared with the baseline self-reported fatigue scores (mean 25.1 points), the score fell by 7.2 points for patients on hydrocortisone and by 3.3 points for those on placebo (paired difference in mean scores 4.5 points [95% CI 1.2-7.7], p=0.009) [13].
  • FINDINGS: At 66 months' follow-up, the low-dose and normal-dose groups were similar in mean serum creatinine (182 [SD 160] vs 184 [157] micromol/L; p=0.9) and mean creatinine clearance (47.5 [25.1] vs 45.3 (22.5] mL/min; p=0.6) [14].

Chemical compound and disease context of VPS24

  • Significantly higher total body weight (67.5 +/- 12.9 vs. 64.1 +/- 12.2 kg, P = 0.03) and BMI (26.3 +/- 4.7 vs. 25.1 +/- 4.5 kg/m2, P = 0.03) was observed in heterozygote women compared with normal subjects (homozygous for tryptophan) [15].
  • The mean duration of "at least Grade 3" mucositis (WHO) was 25.1 days versus 49.2 days with and without amifostine (p = 0.03) [16].
  • Of 149 individuals evaluated, 33% were women, whose mean age was 25.1 years; 93% received a diagnosis of heroin dependence and 71% of cocaine dependence [17].
  • RESULTS: In all but 2 cases, seizure duration was significantly longer in the remifentanil group than in the control group (motor seizure 53.7 +/- 28.3 seconds vs. 29.5 +/- 10.9 seconds, t = 4.017, P = 0.0007; Electroencephalographic (EEG) seizures 60.8 +/- 25.1 seconds vs. 40.1 +/- 17.0 seconds, t = 3.971, P = 0.001) [18].
  • Group A had a predominance of atrioventricular block (61.2 versus 15.5%, P < 0.0004), peak creatine kinase MB (82.5 +/- 22.4 versus 65.2 +/- 25.1 IU/l, P < 0.05), congestive heart failure or cardiogenic shock (57.1 versus 18.9%, P < 0.002), and proximal right coronary artery occlusion (80.4 versus 25.0%, P < 0.001) [19].

Biological context of VPS24

  • We propose that 25.1 (neuroendocrine differentiation factor) together with IGF-binding protein-related protein 1 can induce neuroendocrine cell differentiation in prostate cancer cells [2].
  • The core structure of CHMP3 folds into a flat helical arrangement that assembles into a lattice, mainly via two different dimerization modes, and unilaterally exposes a highly basic surface [3].
  • Mean left ventricular ejection fraction rose from 29.6 +/- 17.7% to 42.7 +/- 22.3% (p less than .05) after 3 months of minoxidil treatment (this result was influenced largely by responses in two patients), and remained unchanged (at 25.1 +/- 16.6%) after 3 months of placebo [20].
  • The prevalence of non-MM genotypes was higher in patients with hyperferritinemia than in those without (28/195, 14% vs. 10/158, 6%, P = .016), and AAT mutations were associated with higher prevalence of sinusoidal siderosis (17/27, 63% vs. 70/180, 39%; P = .02), and sinusoidal/total iron score (46.3 +/- 38% vs. 25.1 +/- 35%, P = .01) [21].
  • RESULTS: We showed that an NF-kappaB binding site polymorphism (known to be functionally relevant) in the TNF promoter region was present in 51.8% of patients with ACA and 16.3% of patients without ACA (chi(2) = 25.1, P = 0.000004 [corrected P = 0.00002]) [22].

Anatomical context of VPS24

  • Overexpressed hVps24 also associated with membranes and perturbed endosome structure but only when fused to green fluorescent protein [23].
  • To explore this relationship, we studied interactions among the human ESCRT-III components hSnf7-1 and hVps24, membranes, and SKD1 [23].
  • The present data suggest that mac25/IGFBP-rP1 and 25.1 may play a functional role in the NE differentiation of NSCLC cell lines and may provide a novel therapeutic target for treating lung cancers, in particular NSCLC with NE differentiation [1].
  • The concentrations of GTN in the pulmonary artery and systemic artery were similar (29.8 ng/ml +/- 52.8 and 25.1 +/- 48.4 ng/ml, respectively) and considerably higher than the concentration in the peripheral vein (7.3 +/- 15.4 ng/ml) [24].
  • Left ventricular inflow and pulmonary vein flow patterns were assessed by Doppler echocardiography in 88 beta-thalassemia major patients with normal left ventricular systolic function; 34 were young (age, 15.1 +/- 3.2 years) and 54 were adults (age, 25.1 +/- 3.6 years) [25].

Associations of VPS24 with chemical compounds

  • An increase and sustained activation of adenosine 3',5'-cyclic monophosphate (cAMP) levels induced NE-like differentiation in NSCLC cell lines, and a concomitant increase in the expression of mac25/IGFBP-rP1 and 25.1 was observed during the cAMP-regulated differentiation of NCI-H157 cells, suggesting the involvement of these proteins [1].
  • Glucose effectiveness (SG) was slightly less repeatable, with an average interday variability of 25.1 +/- 8.8% [26].
  • The corresponding 21- and 22-residue C-terminal analogues of C3a (Y21R and Y21) were less potent than intact factor exhibiting EC50 values of 10.9 and 25.1 microM, respectively [27].
  • Ethenocytosine base-paired with guanine within a CpG site (i.e. CpG.(epsilon)C-DNA) was by far the best substrate having a specificity constant (k(2)/K(d)) of 25.1 x 10(6) m(-1) s(-1) [28].
  • Similarly, the concentration of procainamide resulting in 50% prolongation of accessory pathway block cycle length in the anterograde direction (25.1 [-4.60 +/- 0.13] mumol/liter) was less than in the retrograde direction (52.5 [-4.28 +/- 0.07] mumol/liter, p = 0.01) [29].

Physical interactions of VPS24

  • AMSH also interacts with mVps24/CHMP3, a component of ESCRT III complex, and this interaction is reinforced through simultaneous STAM binding [30].

Regulatory relationships of VPS24


Other interactions of VPS24

  • Furthermore, the collective overexpression of mac25/IGFBP-rP1 and 25.1 in NSCLC cells induced NE-like differentiation as early as 6 h postinfection [1].
  • Immunocytochemical techniques indicate that this protein, 25.1, and intracellular IGF-binding protein-related protein 1 colocalize in the nucleus [2].
  • Moreover, depletion of Tsg101 but not of hVps24 caused a major fraction of internalized EGF to accumulate in nonacidified endosomes [31].
  • Depletion of hVps24 by siRNA showed that this ESCRT subunit, like Tsg101, is important for degradation of the epidermal growth factor (EGF) receptor (EGFR) and for transport of the receptor from early endosomes to lysosomes [31].
  • Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence [32].

Analytical, diagnostic and therapeutic context of VPS24

  • These subjects were compared with 18 healthy control women (mean age, 25.1 +/- 5.8 years).Intervention The 5-HT1A receptor binding was measured using positron emission tomography imaging and a specific 5-HT1A receptor antagonist, [carbonyl-11C]WAY-100635 [33].
  • Left ventricular (LV) ejection fraction increased from 25.1 +/- 6% before surgery to 28.2 +/- 6.7% with the stimulator on after cardiomyoplasty (P = .04) [34].
  • Electron microscopy of hVps24-depleted cells showed an accumulation of EGFRs in MVEs that were significantly smaller than those in control cells, probably because of an impaired fusion with lyso-bisphosphatidic acid-positive late endosomes/lysosomes [31].
  • RESULTS: Colloid osmotic pressure was significantly lower in the DHF group (20.5 +/- 5 mm Hg) than in the SHF group (24.2 +/- 3.7 mm Hg, p < 0.001), pulmonary disease group (25.1 +/- 4.2 mm Hg, p < 0.001), or normal control group (24.7 +/- 3 mm Hg) [35].
  • After 12 mo of peritoneal dialysis, the amount of body fat increased markedly (19.0 +/- 1.5 to 25.1 +/- 2.2 kg; P < 0.001), and the changes in serum leptin concentrations correlated significantly (rho = 0.69; P < 0.01) to the changes in the body fat content [36].


  1. Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1. Walker, G.E., Antoniono, R.J., Ross, H.J., Paisley, T.E., Oh, Y. Oncogene (2006) [Pubmed]
  2. Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. Wilson, E.M., Oh, Y., Hwa, V., Rosenfeld, R.G. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  3. Structural basis for budding by the ESCRT-III factor CHMP3. Muzioł, T., Pineda-Molina, E., Ravelli, R.B., Zamborlini, A., Usami, Y., Göttlinger, H., Weissenhorn, W. Dev. Cell (2006) [Pubmed]
  4. The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases. Fenwick, S.W., Toogood, G.J., Lodge, J.P., Hull, M.A. Gastroenterology (2003) [Pubmed]
  5. Sleep apnea in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the sleep heart health study. Unruh, M.L., Sanders, M.H., Redline, S., Piraino, B.M., Umans, J.G., Hammond, T.C., Sharief, I., Punjabi, N.M., Newman, A.B. J. Am. Soc. Nephrol. (2006) [Pubmed]
  6. An 18-year follow-up of overweight and risk of Alzheimer disease. Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., Skoog, I. Arch. Intern. Med. (2003) [Pubmed]
  7. Comparison of energy expenditure estimates from doubly labeled water, a physical activity questionnaire, and physical activity records. Conway, J.M., Seale, J.L., Jacobs, D.R., Irwin, M.L., Ainsworth, B.E. Am. J. Clin. Nutr. (2002) [Pubmed]
  8. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. Lithell, H., Hansson, L., Skoog, I., Elmfeldt, D., Hofman, A., Olofsson, B., Trenkwalder, P., Zanchetti, A. J. Hypertens. (2003) [Pubmed]
  9. Psychopathological and social status of patients with affective, schizophrenic and schizoaffective disorders after long-term course. Marneros, A., Deister, A., Rohde, A. Acta psychiatrica Scandinavica. (1990) [Pubmed]
  10. Digoxin therapy and mortality after myocardial infarction. Experience in the MILIS Study. Muller, J.E., Turi, Z.G., Stone, P.H., Rude, R.E., Raabe, D.S., Jaffe, A.S., Gold, H.K., Gustafson, N., Poole, W.K., Passamani, E. N. Engl. J. Med. (1986) [Pubmed]
  11. Effects of losartan on cardiovascular morbidity and mortality in patients with isolated systolic hypertension and left ventricular hypertrophy: a Losartan Intervention for Endpoint Reduction (LIFE) substudy. Kjeldsen, S.E., Dahlöf, B., Devereux, R.B., Julius, S., Aurup, P., Edelman, J., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristianson, K., Lederballe-Pedersen, O., Lindholm, L.H., Nieminen, M.S., Omvik, P., Oparil, S., Snapinn, S., Wedel, H. JAMA (2002) [Pubmed]
  12. Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. Scolnik, D., Nulman, I., Rovet, J., Gladstone, D., Czuchta, D., Gardner, H.A., Gladstone, R., Ashby, P., Weksberg, R., Einarson, T. JAMA (1994) [Pubmed]
  13. Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. Cleare, A.J., Heap, E., Malhi, G.S., Wessely, S., O'Keane, V., Miell, J. Lancet (1999) [Pubmed]
  14. Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens. Dantal, J., Hourmant, M., Cantarovich, D., Giral, M., Blancho, G., Dreno, B., Soulillou, J.P. Lancet (1998) [Pubmed]
  15. The beta 3-adrenergic receptor gene Trp64Arg mutation is overrepresented in obese women. Effects on weight, BMI, abdominal fat, blood pressure, and reproductive history in an elderly Australian population. Kurabayashi, T., Carey, D.G., Morrison, N.A. Diabetes (1996) [Pubmed]
  16. A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma. Bourhis, J., De Crevoisier, R., Abdulkarim, B., Deutsch, E., Lusinchi, A., Luboinski, B., Wibault, P., Eschwege, F. Int. J. Radiat. Oncol. Biol. Phys. (2000) [Pubmed]
  17. Psychiatric comorbidity in young heroin users. Rodríguez-Llera, M.C., Domingo-Salvany, A., Brugal, M.T., Silva, T.C., Sánchez-Niubó, A., Torrens, M. Drug and alcohol dependence. (2006) [Pubmed]
  18. Remifentanil supplementation of propofol during electroconvulsive therapy: effect on seizure duration and cardiovascular stability. Vishne, T., Aronov, S., Amiaz, R., Etchin, A., Grunhaus, L. The journal of ECT. (2005) [Pubmed]
  19. Mortality is not increased with inferior infarction associated with right ventricular infarction and atrioventricular block. Ramires, J.A., Solimene, M.C., Savioli, R.M., Grandini Júnior, L., Cesar, L.A., da Luz, P.L., Pileggi, F. Coron. Artery Dis. (1993) [Pubmed]
  20. Minoxidil in patients with chronic left heart failure: contrasting hemodynamic and clinical effects in a controlled trial. Franciosa, J.A., Jordan, R.A., Wilen, M.M., Leddy, C.L. Circulation (1984) [Pubmed]
  21. alpha1-Antitrypsin mutations in NAFLD: High prevalence and association with altered iron metabolism but not with liver damage. Valenti, L., Dongiovanni, P., Piperno, A., Fracanzani, A.L., Maggioni, M., Rametta, R., Loria, P., Casiraghi, M.A., Suigo, E., Ceriani, R., Remondini, E., Trombini, P., Fargion, S. Hepatology (2006) [Pubmed]
  22. The TNF-863A allele strongly associates with anticentromere antibody positivity in scleroderma. Sato, H., Lagan, A.L., Alexopoulou, C., Vassilakis, D.A., Ahmad, T., Pantelidis, P., Veeraraghavan, S., Renzoni, E., Denton, C., Black, C., Wells, A.U., du Bois, R.M., Welsh, K.I. Arthritis Rheum. (2004) [Pubmed]
  23. Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. Lin, Y., Kimpler, L.A., Naismith, T.V., Lauer, J.M., Hanson, P.I. J. Biol. Chem. (2005) [Pubmed]
  24. Arterial-venous nitroglycerin gradient during intravenous infusion in man. Armstrong, P.W., Moffat, J.A., Marks, G.S. Circulation (1982) [Pubmed]
  25. Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Kremastinos, D.T., Tsiapras, D.P., Tsetsos, G.A., Rentoukas, E.I., Vretou, H.P., Toutouzas, P.K. Circulation (1993) [Pubmed]
  26. Repeatability of insulin sensitivity and glucose effectiveness from the minimal model. Implications for study design. Steil, G.M., Murray, J., Bergman, R.N., Buchanan, T.A. Diabetes (1994) [Pubmed]
  27. A mechanism of action for anaphylatoxin C3a stimulation of mast cells. Mousli, M., Hugli, T.E., Landry, Y., Bronner, C. J. Immunol. (1992) [Pubmed]
  28. The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine. Abu, M., Waters, T.R. J. Biol. Chem. (2003) [Pubmed]
  29. Differential effect of intravenous procainamide on anterograde and retrograde accessory pathway refractoriness. Leitch, J.W., Klein, G.J., Yee, R., Feldman, R.D., Brown, J. J. Am. Coll. Cardiol. (1992) [Pubmed]
  30. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. McCullough, J., Row, P.E., Lorenzo, O., Doherty, M., Beynon, R., Clague, M.J., Urbé, S. Curr. Biol. (2006) [Pubmed]
  31. The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Bache, K.G., Stuffers, S., Malerød, L., Slagsvold, T., Raiborg, C., Lechardeur, D., Wälchli, S., Lukacs, G.L., Brech, A., Stenmark, H. Mol. Biol. Cell (2006) [Pubmed]
  32. Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. Breslin, M.B., Zhu, M., Notkins, A.L., Lan, M.S. Nucleic Acids Res. (2002) [Pubmed]
  33. Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635. Bailer, U.F., Frank, G.K., Henry, S.E., Price, J.C., Meltzer, C.C., Weissfeld, L., Mathis, C.A., Drevets, W.C., Wagner, A., Hoge, J., Ziolko, S.K., McConaha, C.W., Kaye, W.H. Arch. Gen. Psychiatry (2005) [Pubmed]
  34. Clinical study of the effects of latissimus dorsi muscle flap stimulation after cardiomyoplasty. Hagège, A.A., Desnos, M., Fernandez, F., Besse, B., Mirochnik, N., Castaldo, M., Chachques, J.C., Carpentier, A., Guérot, C. Circulation (1995) [Pubmed]
  35. Hypoalbuminemia in elderly patients with acute diastolic heart failure. Arquès, S., Ambrosi, P., Gélisse, R., Luccioni, R., Habib, G. J. Am. Coll. Cardiol. (2003) [Pubmed]
  36. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. Heimbürger, O., Lönnqvist, F., Danielsson, A., Nordenström, J., Stenvinkel, P. J. Am. Soc. Nephrol. (1997) [Pubmed]
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