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Gene Review

EAF2  -  ELL associated factor 2

Homo sapiens

Synonyms: BM-040, BM040, ELL-associated factor 2, TRAITS, Testosterone-regulated apoptosis inducer and tumor suppressor protein, ...
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Disease relevance of EAF2


Psychiatry related information on EAF2


High impact information on EAF2

  • The results support a model according to which 5'-->3' and 3'-->5' exonucleases are involved in maturation of U17 and U19 RNAs and that excised and debranched introns are the substrates of the processing reaction [10].
  • Single-locus and haplotype analyses were performed using the Family-Based Association Test and the Transmission Disequilibrium Test. Traits examined included DSM-IV OCD diagnosis and highest lifetime symptom severity as measured using the Yale-Brown Obsessive-Compulsive Scale [11].
  • In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity [12].
  • EAF2 is highly homologous to EAF1, with 58% identity and 74% amino acid conservation [13].
  • Using retroviral bone marrow transduction, we observed that a heterologous fusion of EAF2 to MLL immortalized hematopoietic progenitor cells [13].

Chemical compound and disease context of EAF2

  • Based on prior research, it was hypothesized that the correlations among childhood, adult, and full APD criteria and PCL-R Total, Factor 1 (Psychopathic Personality Traits), and Factor 2 (Antisocial Lifestyle) scores would differ for men and women [14].

Biological context of EAF2


Anatomical context of EAF2


Associations of EAF2 with chemical compounds

  • CONCLUSIONS: Lesions within the dopamine-rich ventral putamen, which is part of the ventral or limbic striatum, tended to increase the risk of ADHD/Traits [8].
  • A meta-analysis of these findings disclosed that Factor 2 (Antisocial/Unstable Lifestyle) correlated moderately well with institutional adjustment and recidivism, whereas Factor 1 (Affective/Interpersonal Traits) was less robustly associated with these outcomes [18].
  • Running velocities corresponding to all lactate concentrations showed no significant differences at all age groups, but heart rates in soccer players in the U21 and U19 age groups were significantly lower than in the U17 age group [19].

Physical interactions of EAF2


Other interactions of EAF2


Analytical, diagnostic and therapeutic context of EAF2


  1. ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. Xiao, W., Jiang, F., Wang, Z. Prostate (2006) [Pubmed]
  2. Human Domain Antibodies against Virulence Traits of Candida albicans Inhibit Fungus Adherence to Vaginal Epithelium and Protect against Experimental Vaginal Candidiasis. De Bernardis, F., Liu, H., O'mahony, R., La Valle, R., Bartollino, S., Sandini, S., Grant, S., Brewis, N., Tomlinson, I., Basset, R.C., Holton, J., Roitt, I.M., Cassone, A. J. Infect. Dis. (2007) [Pubmed]
  3. Attention deficit hyperactivity disorder and neurocognitive correlates after childhood stroke. Max, J.E., Mathews, K., Manes, F.F., Robertson, B.A., Fox, P.T., Lancaster, J.L., Lansing, A.E., Schatz, A., Collings, N. Journal of the International Neuropsychological Society : JINS. (2003) [Pubmed]
  4. Inheritance of reproductive traits of female common ducks (Anas platyrhynchos) in pure breeding and in inter-generic crossbreeding with muscovy ducks (Cairina moschata). Brun, J.M., Larzul, C. Br. Poult. Sci. (2003) [Pubmed]
  5. The Nithsdale Schizophrenia Surveys. XIII. Parental rearing patterns, current symptomatology and relatives' expressed emotion. McCreadie, R.G., Williamson, D.J., Athawes, R.W., Connolly, M.A., Tilak-Singh, D. The British journal of psychiatry : the journal of mental science. (1994) [Pubmed]
  6. Temperament and hypothalamic-pituitary-adrenal axis function in healthy adults. Tyrka, A.R., Mello, A.F., Mello, M.F., Gagne, G.G., Grover, K.E., Anderson, G.M., Price, L.H., Carpenter, L.L. Psychoneuroendocrinology (2006) [Pubmed]
  7. Covariance of personality, neurocognition, and schizophrenia spectrum traits in the community. Tien, A.Y., Costa, P.T., Eaton, W.W. Schizophr. Res. (1992) [Pubmed]
  8. Putamen lesions and the development of attention-deficit/hyperactivity symptomatology. Max, J.E., Fox, P.T., Lancaster, J.L., Kochunov, P., Mathews, K., Manes, F.F., Robertson, B.A., Arndt, S., Robin, D.A., Lansing, A.E. Journal of the American Academy of Child and Adolescent Psychiatry. (2002) [Pubmed]
  9. Fatigue in patients with cancers of the breast or prostate undergoing radical radiotherapy. Stone, P., Richards, M., A'Hern, R., Hardy, J. Journal of pain and symptom management. (2001) [Pubmed]
  10. Exonucleolytic processing of small nucleolar RNAs from pre-mRNA introns. Kiss, T., Filipowicz, W. Genes Dev. (1995) [Pubmed]
  11. Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Arnold, P.D., Sicard, T., Burroughs, E., Richter, M.A., Kennedy, J.L. Arch. Gen. Psychiatry (2006) [Pubmed]
  12. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Kong, S.E., Banks, C.A., Shilatifard, A., Conaway, J.W., Conaway, R.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. Simone, F., Luo, R.T., Polak, P.E., Kaberlein, J.J., Thirman, M.J. Blood (2003) [Pubmed]
  14. Gender differences in the relationship of antisocial personality disorder criteria to Psychopathy Checklist-Revised scores. Rutherford, M.J., Alterman, A.I., Cacciola, J.S., McKay, J.R. J. Personal. Disord. (1998) [Pubmed]
  15. Apoptosis induction and growth suppression by U19/Eaf2 is mediated through its ELL-binding domain. Hahn, J., Xiao, W., Jiang, F., Simone, F., Thirman, M.J., Wang, Z. Prostate (2007) [Pubmed]
  16. PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits. Chelala, C., Duchatelet, S., Joffret, M.L., Bergholdt, R., Dubois-Laforgue, D., Ghandil, P., Pociot, F., Caillat-Zucman, S., Timsit, J., Julier, C. Diabetes (2007) [Pubmed]
  17. Occlusal molar surfaces in females with Turner's syndrome. Maćesić, M., Kaić, Z., Dumancić, J., Poje, Z., Dumić, M. Collegium antropologicum. (2003) [Pubmed]
  18. Predicting institutional adjustment and recidivism with the psychopathy checklist factor scores: a meta-analysis. Walters, G.D. Law and human behavior. (2003) [Pubmed]
  19. Running velocities and heart rates at fixed blood lactate concentrations in young soccer players. Guner, R., Kunduracioglu, B., Ulkar, B. Advances in therapy. (2006) [Pubmed]
  20. Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population. Kim, S.J., Kim, Y.S., Kim, C.H., Lee, H.S. Yonsei Med. J. (2006) [Pubmed]
  21. Personality disorder traits in patients with epilepsy. Swinkels, W.A., Duijsens, I.J., Spinhoven, P. Seizure : the journal of the British Epilepsy Association. (2003) [Pubmed]
  22. Third international meeting on the genetic epidemiology of complex traits, April 4-6, 2002, Cambridge, UK. John, S., Jenkins, S. Hum. Mutat. (2002) [Pubmed]
  23. Age changes in personality and their origins: comment on Roberts, Walton, and Viechtbauer (2006). Costa, P.T., McCrae, R.R. Psychological bulletin. (2006) [Pubmed]
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