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Gene Review

NDJ1  -  Ndj1p

Saccharomyces cerevisiae S288c

Synonyms: Non-disjunction protein 1, TAM1, Telomere-associated meiosis protein 1, YOL104C
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High impact information on NDJ1

  • Deletion of NDJ1 (ndj1Delta) caused nondisjunction, impaired distributive segregation of linear chromosomes, and disordered the distribution of telomeric Rap1p, but it did not affect distributive segregation of circular plasmids [1].
  • The Saccharomyces cerevisiae gene NDJ1 (nondisjunction) encodes a protein that accumulates at telomeres during meiotic prophase [1].
  • Ndj1p, a meiotic telomere protein required for normal chromosome synapsis and segregation in yeast [1].
  • Since ndj1Delta meiocytes fail to cluster their telomeres at any prophase stage, Ndj1p is the first protein shown to be required for bouquet formation in a synaptic organism [2].
  • We explored the role of Ndj1 in meiotic recombination, which occurs through the formation and repair of programmed double-strand breaks [3].

Biological context of NDJ1

  • The simultaneous defects in synapsis and interference observed in msh4 (and also zip1 and ndj1/tam1) suggest a role for the SC in mediating interference [4].

Anatomical context of NDJ1


Analytical, diagnostic and therapeutic context of NDJ1

  • Consistent with this hypothesis, fluorescent in situ hybridization demonstrates that a circular chromosome has a reduced capacity to pair with its homolog, and a telomere-associated meiotic protein (Ndj1) is required to delay sporulation in disomes [5].


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