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Gene Review:

UBC11 - putative E2 ubiquitin-protein ligase UBC11

Saccharomyces cerevisiae S288c

Synonyms: O6268, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-18 kDa, Ubiquitin-protein ligase, YOR339C

Townsley, F.M. et al., Passmore, L.A. et al., Morrione, A. et al., Mayer, R.J. et al.

Townsley, Ruderman, Morrione, Plant, Valentinis, Staub, Kumar, Rotin, Baserga,

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Disease relevance of UBC11

Gankyrin is found in other complexes that contain Rb (retinoblastoma protein) and the ubiquitin protein ligase Mdm2 (murine double minute 2) [1].

High impact information on UBC11

We have isolated a mouse cDNA clone containing the C2 domain of mouse Nedd4, a ubiquitin protein ligase (E3) that also contains a hect (homologous to the E6-AP carboxyl-terminus) domain and three WW domains [2].
We have disrupted the UBC11 gene and found it is not essential for yeast cell viability even when combined with deletion of UBC4, a gene that has also been implicated in mitotic cyclin destruction [3].
UBC11 is the Saccharomyces cerevisiae gene that is most similar in sequence to E2-C, a ubiquitin carrier protein required for the destruction of mitotic cyclins and proteins that maintain sister chromatid cohesion in animal cells and in Schizosaccharomyces pombe [3].
The anaphase-promoting complex (APC) is a central regulator of the eukaryotic cell cycle and functions as an E3 ubiquitin protein ligase to catalyze the ubiquitination of a number of cell cycle regulatory proteins [4].

References

Gankyrin, the 26 S proteasome, the cell cycle and cancer. Mayer, R.J., Fujita, J. Biochem. Soc. Trans. (2006) [Pubmed]
mGrb10 interacts with Nedd4. Morrione, A., Plant, P., Valentinis, B., Staub, O., Kumar, S., Rotin, D., Baserga, R. J. Biol. Chem. (1999) [Pubmed]
Functional analysis of the Saccharomyces cerevisiae UBC11 gene. Townsley, F.M., Ruderman, J.V. Yeast (1998) [Pubmed]
Purification and assay of the budding yeast anaphase-promoting complex. Passmore, L.A., Barford, D., Harper, J.W. Meth. Enzymol. (2005) [Pubmed]

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AgaP_AGAP006238	Anopheles gambiae str. PEST
UBC19	Arabidopsis thaliana
UBC20	Arabidopsis thaliana
UBE2C	Bos taurus
UBE2C	Canis lupus familiaris
ube2c	Danio rerio
vih	Drosophila melanogaster
UBE2C	Gallus gallus
UBE2C	Homo sapiens
UBE2C	Macaca mulatta
MGG_03728	Magnaporthe oryzae 70-15
Ube2c	Mus musculus
Os01g0273100	Oryza sativa Japonica Group
UBE2C	Pan troglodytes
Ube2c	Rattus norvegicus
ubc11	Schizosaccharomyces pombe 972h-
ube2c	Xenopus (Silurana) tropicalis

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