Gene Review:
UBC4 - E2 ubiquitin-conjugating protein UBC4
Saccharomyces cerevisiae S288c
Synonyms:
Ubiquitin carrier protein 4, Ubiquitin-conjugating enzyme E2 4, Ubiquitin-protein ligase 4, YBR0745, YBR082C
- Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome. Tongaonkar, P., Chen, L., Lambertson, D., Ko, B., Madura, K. Mol. Cell. Biol. (2000)
- A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. King, R.W., Peters, J.M., Tugendreich, S., Rolfe, M., Hieter, P., Kirschner, M.W. Cell (1995)
- An essential ubiquitin-conjugating enzyme with tissue and developmental specificity in th nematode Caenorhabditis elegans. Zhen, M., Schein, J.E., Baillie, D.L., Candido, E.P. EMBO J. (1996)
- The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants. Kölling, R., Hollenberg, C.P. EMBO J. (1994)
- Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. Seufert, W., Jentsch, S. EMBO J. (1990)
- Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin. Seino, H., Kishi, T., Nishitani, H., Yamao, F. Mol. Cell. Biol. (2003)
- Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E2(17)kB) highly expressed in rat testis. Wing, S.S., Jain, P. Biochem. J. (1995)
- Functional analysis of the Saccharomyces cerevisiae UBC11 gene. Townsley, F.M., Ruderman, J.V. Yeast (1998)
- Creation of a pluripotent ubiquitin-conjugating enzyme. Ptak, C., Gwozd, C., Huzil, J.T., Gwozd, T.J., Garen, G., Ellison, M.J. Mol. Cell. Biol. (2001)
- Cloning of a 16-kDa ubiquitin carrier protein from wheat and Arabidopsis thaliana. Identification of functional domains by in vitro mutagenesis. Sullivan, M.L., Vierstra, R.D. J. Biol. Chem. (1991)
- Identification of rabbit reticulocyte E217K as a UBC7 homologue and functional characterization of its core domain loop. Lin, H., Wing, S.S. J. Biol. Chem. (1999)
- The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. Kragt, A., Voorn-Brouwer, T., van den Berg, M., Distel, B. J. Biol. Chem. (2005)
- Overexpression of the ubiquitin-conjugating enzyme Cdc34 confers resistance to methylmercury in Saccharomyces cerevisiae. Furuchi, T., Hwang, G.W., Naganuma, A. Mol. Pharmacol. (2002)
- The yeast UBC4 ubiquitin conjugating enzyme monoubiquitinates itself in vivo: evidence for an E2-E2 homointeraction. Gwozd, C.S., Arnason, T.G., Cook, W.J., Chau, V., Ellison, M.J. Biochemistry (1995)
- Yeast 2 microm plasmid copy number is elevated by a mutation in the nuclear gene UBC4. Sleep, D., Finnis, C., Turner, A., Evans, L. Yeast (2001)
- Saccharomyces cerevisiae Ub-conjugating enzyme Ubc4 binds the proteasome in the presence of translationally damaged proteins. Chuang, S.M., Madura, K. Genetics (2005)
- A rabbit reticulocyte ubiquitin carrier protein that supports ubiquitin-dependent proteolysis (E214k) is homologous to the yeast DNA repair gene RAD6. Wing, S.S., Dumas, F., Banville, D. J. Biol. Chem. (1992)
- UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation. Seufert, W., McGrath, J.P., Jentsch, S. EMBO J. (1990)
- Ubiquitination of the peroxisomal targeting signal type 1 receptor, Pex5p, suggests the presence of a quality control mechanism during peroxisomal matrix protein import. Kiel, J.A., Emmrich, K., Meyer, H.E., Kunau, W.H. J. Biol. Chem. (2005)