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Gene Review:

GTT1 - bifunctional glutathione...

Saccharomyces cerevisiae S288c

Synonyms: GST-I, Glutathione S-transferase 1, YIR038C

Choi, J.H. et al., Melissis, S.C. et al., Adamis, P.D. et al., Sharma, K.G. et al., Castro, F.A. et al.

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High impact information on GTT1

Strains deleted for GTT1 and/or GTT2 are viable but exhibit increased sensitivity to heat shock in stationary phase and limited ability to grow at 39 degreesC [1].
In the investigation of phase II (conjugation), it was found that glutathione S-transferases, encoded by GTT1 and GTT2,do not appear to play a role in this process [2].
In particular, the affinity adsorbent comprising as terminal biomimetic moiety glutathionesulfonic acid (BM1), exhibited the highest purifying ability for FaDH and GSTI, whereas, the affinity adsorbent comprising as terminal biomimetic moiety methyl-glutathione (BM2) exhibited the highest purifying ability for GSHR [3].

Associations of GTT1 with chemical compounds

In this paper we report an identification and characterization of the two Saccharomyces cerevisiae genes, GTT1 and GTT2 (glutathione transferase 1 and 2), coding for functional GST enzymes [1].
Using Saccharomyces cerevisiae as experimental model, we observed that cells mutated in the GTT1 or GTT2 genes showed twice as much cadmium absorption than the control strain [4].
This assessment was corroborated by the increase of GTT2 expression, and not of GTT1, after menadione treatment [5].

References

A novel membrane-bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae. Choi, J.H., Lou, W., Vancura, A. J. Biol. Chem. (1998) [Pubmed]
The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. Sharma, K.G., Kaur, R., Bachhawat, A.K. Arch. Microbiol. (2003) [Pubmed]
New family of glutathionyl-biomimetic ligands for affinity chromatography of glutathione-recognising enzymes. Melissis, S.C., Rigden, D.J., Clonis, Y.D. Journal of chromatography. A. (2001) [Pubmed]
The role of glutathione transferases in cadmium stress. Adamis, P.D., Gomes, D.S., Pinto, M.L., Panek, A.D., Eleutherio, E.C. Toxicol. Lett. (2004) [Pubmed]
Menadione stress in Saccharomyces cerevisiae strains deficient in the glutathione transferases. Castro, F.A., Herdeiro, R.S., Panek, A.D., Eleutherio, E.C., Pereira, M.D. Biochim. Biophys. Acta (2007) [Pubmed]

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