The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GTT1  -  bifunctional glutathione...

Saccharomyces cerevisiae S288c

Synonyms: GST-I, Glutathione S-transferase 1, YIR038C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on GTT1

  • Strains deleted for GTT1 and/or GTT2 are viable but exhibit increased sensitivity to heat shock in stationary phase and limited ability to grow at 39 degreesC [1].
  • In the investigation of phase II (conjugation), it was found that glutathione S-transferases, encoded by GTT1 and GTT2,do not appear to play a role in this process [2].
  • In particular, the affinity adsorbent comprising as terminal biomimetic moiety glutathionesulfonic acid (BM1), exhibited the highest purifying ability for FaDH and GSTI, whereas, the affinity adsorbent comprising as terminal biomimetic moiety methyl-glutathione (BM2) exhibited the highest purifying ability for GSHR [3].

Associations of GTT1 with chemical compounds


  1. A novel membrane-bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae. Choi, J.H., Lou, W., Vancura, A. J. Biol. Chem. (1998) [Pubmed]
  2. The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. Sharma, K.G., Kaur, R., Bachhawat, A.K. Arch. Microbiol. (2003) [Pubmed]
  3. New family of glutathionyl-biomimetic ligands for affinity chromatography of glutathione-recognising enzymes. Melissis, S.C., Rigden, D.J., Clonis, Y.D. Journal of chromatography. A. (2001) [Pubmed]
  4. The role of glutathione transferases in cadmium stress. Adamis, P.D., Gomes, D.S., Pinto, M.L., Panek, A.D., Eleutherio, E.C. Toxicol. Lett. (2004) [Pubmed]
  5. Menadione stress in Saccharomyces cerevisiae strains deficient in the glutathione transferases. Castro, F.A., Herdeiro, R.S., Panek, A.D., Eleutherio, E.C., Pereira, M.D. Biochim. Biophys. Acta (2007) [Pubmed]
WikiGenes - Universities