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Gene Review

GTT2  -  glutathione transferase GTT2

Saccharomyces cerevisiae S288c

Synonyms: GST-II, Glutathione S-transferase 2, L0560, YLL060C
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High impact information on GTT2

  • Rather, the mechanism appears to be mediated via glutathione conjugation and removal from the cell because it is absent in strains lacking glutathione-S-transferases (GTT1, GTT2) or the GS-X pump (YCF1) [1].
  • Strains deleted for GTT1 and/or GTT2 are viable but exhibit increased sensitivity to heat shock in stationary phase and limited ability to grow at 39 degreesC [2].

Biological context of GTT2


Associations of GTT2 with chemical compounds


  1. The yeast glutaredoxins are active as glutathione peroxidases. Collinson, E.J., Wheeler, G.L., Garrido, E.O., Avery, A.M., Avery, S.V., Grant, C.M. J. Biol. Chem. (2002) [Pubmed]
  2. A novel membrane-bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae. Choi, J.H., Lou, W., Vancura, A. J. Biol. Chem. (1998) [Pubmed]
  3. Characterization, expression and regulation of a third gene encoding glutathione S-transferase from the fission yeast. Shin, Y.H., Park, E.H., Fuchs, J.A., Lim, C.J. Biochim. Biophys. Acta (2002) [Pubmed]
  4. The role of glutathione transferases in cadmium stress. Adamis, P.D., Gomes, D.S., Pinto, M.L., Panek, A.D., Eleutherio, E.C. Toxicol. Lett. (2004) [Pubmed]
  5. Menadione stress in Saccharomyces cerevisiae strains deficient in the glutathione transferases. Castro, F.A., Herdeiro, R.S., Panek, A.D., Eleutherio, E.C., Pereira, M.D. Biochim. Biophys. Acta (2007) [Pubmed]
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