Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GTT2 - glutathione transferase GTT2

Saccharomyces cerevisiae S288c

Synonyms: GST-II, Glutathione S-transferase 2, L0560, YLL060C

Shin, Y.H. et al., Collinson, E.J. et al., Adamis, P.D. et al., Choi, J.H. et al., Castro, F.A. et al.

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High impact information on GTT2

Rather, the mechanism appears to be mediated via glutathione conjugation and removal from the cell because it is absent in strains lacking glutathione-S-transferases (GTT1, GTT2) or the GS-X pump (YCF1) [1].
Strains deleted for GTT1 and/or GTT2 are viable but exhibit increased sensitivity to heat shock in stationary phase and limited ability to grow at 39 degreesC [2].

Biological context of GTT2

However, the synthesis of beta-galactosidase from the fusion plasmid pGY357 was not affected by superoxide-generating menadione, and o-dinitrobenzene, whereas they could significantly induce the expression of the GSTI and GSTII genes of S. pombe [3].

Associations of GTT2 with chemical compounds

Using Saccharomyces cerevisiae as experimental model, we observed that cells mutated in the GTT1 or GTT2 genes showed twice as much cadmium absorption than the control strain [4].
This assessment was corroborated by the increase of GTT2 expression, and not of GTT1, after menadione treatment [5].

References

The yeast glutaredoxins are active as glutathione peroxidases. Collinson, E.J., Wheeler, G.L., Garrido, E.O., Avery, A.M., Avery, S.V., Grant, C.M. J. Biol. Chem. (2002) [Pubmed]
A novel membrane-bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae. Choi, J.H., Lou, W., Vancura, A. J. Biol. Chem. (1998) [Pubmed]
Characterization, expression and regulation of a third gene encoding glutathione S-transferase from the fission yeast. Shin, Y.H., Park, E.H., Fuchs, J.A., Lim, C.J. Biochim. Biophys. Acta (2002) [Pubmed]
The role of glutathione transferases in cadmium stress. Adamis, P.D., Gomes, D.S., Pinto, M.L., Panek, A.D., Eleutherio, E.C. Toxicol. Lett. (2004) [Pubmed]
Menadione stress in Saccharomyces cerevisiae strains deficient in the glutathione transferases. Castro, F.A., Herdeiro, R.S., Panek, A.D., Eleutherio, E.C., Pereira, M.D. Biochim. Biophys. Acta (2007) [Pubmed]

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