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Gene Review

Myo1f  -  myosin IF

Mus musculus

Synonyms: C330006B10Rik, Unconventional myosin-If
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Disease relevance of Myo1f

  • In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response [1].

High impact information on Myo1f

  • Myo1c and Myo1f were mapped by in situ hybridization to the chromosomal regions 11D-11E and 17B-17C, respectively [2].
  • The tail of Myo1f includes (1) a TH-1 region rich in basic residues, which may interact with anionic membrane phospholipids; (2) a TH-2 proline-rich region, expected to contain an ATP-insensitive actin-binding site; and (3) a SH-3 domain found in a variety of cytoskeletal and signaling proteins [2].
  • Modulation of cell adhesion and motility in the immune system by Myo1f [1].
  • Thus, Myo1f directs immune cell motility and innate host defense against infection [1].
  • Cells from Myo1f-deficient mice exhibited abnormally increased adhesion and reduced motility, resulting from augmented exocytosis of beta2 integrin-containing granules [1].

Anatomical context of Myo1f

  • We demonstrated that one of these proteins, Myo1f, is expressed predominantly in the mammalian immune system [1].

Analytical, diagnostic and therapeutic context of Myo1f

  • Northern blot analysis indicated that the genes encoding Myo1c and Myo1f display a widespread tissue expression in the adult mouse [2].


  1. Modulation of cell adhesion and motility in the immune system by Myo1f. Kim, S.V., Mehal, W.Z., Dong, X., Heinrich, V., Pypaert, M., Mellman, I., Dembo, M., Mooseker, M.S., Wu, D., Flavell, R.A. Science (2006) [Pubmed]
  2. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Crozet, F., el Amraoui, A., Blanchard, S., Lenoir, M., Ripoll, C., Vago, P., Hamel, C., Fizames, C., Levi-Acobas, F., Depétris, D., Mattei, M.G., Weil, D., Pujol, R., Petit, C. Genomics (1997) [Pubmed]
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