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Gene Review

SPO13  -  Spo13p

Saccharomyces cerevisiae S288c

Synonyms: Meiosis-specific protein SPO13, Sporulation-specific protein 13, YHR014W
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High impact information on SPO13


Biological context of SPO13


Associations of SPO13 with chemical compounds

  • The meiotic block is not bypassed in backgrounds homozygous for spo13, rad50 delta, or rad9 delta mutations, but is bypassed in the presence of hydroxyurea, a drug known to inhibit DNA chain elongation [7].

Regulatory relationships of SPO13


Other interactions of SPO13

  • The msc (meiotic sister-chromatid recombination) mutants were quantified in spo13 meiosis with respect to meiotic unequal SCR frequency, disome segregation pattern, sporulation frequency, and spore viability [10].
  • Although substantial meiotic recombination was found for these conditional alleles at the restrictive temperature, the level of exchange measured in spo13 meiosis was reduced in some of the monitored intervals, indicating that nondisjunction resulting from a deficit in crossing over could account for SPO13 spore inviability [11].
  • A mutation at the REC102 locus was identified in a screen for yeast mutants that produce inviable spores. rec102 spore lethality is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division [12].
  • The spore inviability of rad58 strains is not rescued by a spo13 mutation [13].
  • Diploids homozygous for a mek1 null mutation produce only 13% viable spores. mek1 spore inviability is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division [14].


  1. The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. Kiburz, B.M., Reynolds, D.B., Megee, P.C., Marston, A.L., Lee, B.H., Lee, T.I., Levine, S.S., Young, R.A., Amon, A. Genes Dev. (2005) [Pubmed]
  2. Spo13 regulates cohesin cleavage. Lee, B.H., Amon, A., Prinz, S. Genes Dev. (2002) [Pubmed]
  3. Stress and developmental regulation of the yeast C-type cyclin Ume3p (Srb11p/Ssn8p). Cooper, K.F., Mallory, M.J., Smith, J.B., Strich, R. EMBO J. (1997) [Pubmed]
  4. Meiotic recombination initiated by a double-strand break in rad50 delta yeast cells otherwise unable to initiate meiotic recombination. Malkova, A., Ross, L., Dawson, D., Hoekstra, M.F., Haber, J.E. Genetics (1996) [Pubmed]
  5. HOP1: a yeast meiotic pairing gene. Hollingsworth, N.M., Byers, B. Genetics (1989) [Pubmed]
  6. Nucleotide sequence and promoter analysis of SPO13, a meiosis-specific gene of Saccharomyces cerevisiae. Buckingham, L.E., Wang, H.T., Elder, R.T., McCarroll, R.M., Slater, M.R., Esposito, R.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. Progression into the first meiotic division is sensitive to histone H2A-H2B dimer concentration in Saccharomyces cerevisiae. Tsui, K., Simon, L., Norris, D. Genetics (1997) [Pubmed]
  8. SPO13 negatively regulates the progression of mitotic and meiotic nuclear division in Saccharomyces cerevisiae. McCarroll, R.M., Esposito, R.E. Genetics (1994) [Pubmed]
  9. The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae. Leem, S.H., Ogawa, H. Nucleic Acids Res. (1992) [Pubmed]
  10. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Thompson, D.A., Stahl, F.W. Genetics (1999) [Pubmed]
  11. Insertional mutations in the yeast HOP1 gene: evidence for multimeric assembly in meiosis. Friedman, D.B., Hollingsworth, N.M., Byers, B. Genetics (1994) [Pubmed]
  12. The rec102 mutant of yeast is defective in meiotic recombination and chromosome synapsis. Bhargava, J., Engebrecht, J., Roeder, G.S. Genetics (1992) [Pubmed]
  13. RAD58 (XRS4)--a new gene in the RAD52 epistasis group. Chepurnaya, O.V., Kozhin, S.A., Peshekhonov, V.T., Korolev, V.G. Curr. Genet. (1995) [Pubmed]
  14. A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Rockmill, B., Roeder, G.S. Genes Dev. (1991) [Pubmed]
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