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Gene Review

REC107  -  Rec107p

Saccharomyces cerevisiae S288c

Synonyms: J1462, MER2, Meiotic recombination protein 2, Recombination protein 107, YJR021C
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High impact information on REC107

  • A genetic selection was devised to recover second-site mutations that bypass the requirement for MER1 in MER2 RNA-splicing [1].
  • The suppressor mutation affects the first residue in U1 snRNA, allowing this nucleotide to base pair with the eighth nucleotide in the MER2 intron [1].
  • The MER2 gene is transcribed in mitosis as well as meiosis; however, the transcript is spliced efficiently to generate a functional gene product only in meiosis [2].
  • The MER2 gene product is essential for meiosis [3].
  • This work defines a yeast splicing enhancer and shows that constitutively expressed and cell type-specific factors combine to regulate splicing of a specific subset of pre-mRNAs including SPO70, MER2, and MER3 [4].

Biological context of REC107

  • This paper presents data to confirm that two of them, REC102 and REC107, are general, meiosis-specific recombination genes that have no detectable role during mitosis [5].
  • Deficiency of recombination in a mre2 mutant that has an amino acid substitution in the N-terminal RRM can be suppressed by the MER2 gene on the multicopy plasmid [6].
  • If DSB formation is blocked (e.g., by a spo11 mutation), dephosphorylation of Mer2 and its dissociation from chromosomes are delayed [7].
  • Mer2 localizes to distinct foci on meiotic chromosomes, with foci maximally abundant prior to the formation of synaptonemal complex [7].
  • The Mer2 protein is present in vegetative cells, but it increases in abundance and becomes phosphorylated specifically during meiotic prophase [7].

Associations of REC107 with chemical compounds

  • Translation of IME1 has been proposed to occur only in meiotic cells; several meiotic transcripts are more stable in acetate medium than in glucose medium; and splicing of MER2 RNA depends on a meiosis-specific gene, MER1 [8].

Physical interactions of REC107

  • Thus, Mer1 interacts directly with a regulatory element in MER2 RNA and promotes splicing [9].

Co-localisations of REC107

  • We have also found that the Mei4 and Rec114 proteins localize to foci on chromosomes and these foci partially colocalize with each other and with Mer2 [7].

Regulatory relationships of REC107


Other interactions of REC107

  • Further analysis showed that the Mre2 protein is involved in meiosis-specific splicing of the MER2 transcripts in cooperation with the Mer1 protein [6].
  • We propose that Mer2, Mei4, and Rec114 form a distinct complex required for DSB formation [7].
  • Therefore, at least one of the functions of the MER1 protein is to mediate splicing of the MER2 transcript [2].

Analytical, diagnostic and therapeutic context of REC107


  1. Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor. Nandabalan, K., Price, L., Roeder, G.S. Cell (1993) [Pubmed]
  2. Meiosis-specific RNA splicing in yeast. Engebrecht, J.A., Voelkel-Meiman, K., Roeder, G.S. Cell (1991) [Pubmed]
  3. Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation. Engebrecht, J., Hirsch, J., Roeder, G.S. Cell (1990) [Pubmed]
  4. A yeast intronic splicing enhancer and Nam8p are required for Mer1p-activated splicing. Spingola, M., Ares, M. Mol. Cell (2000) [Pubmed]
  5. Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107/MER2. Cool, M., Malone, R.E. Mol. Cell. Biol. (1992) [Pubmed]
  6. Functions of the yeast meiotic recombination genes, MRE11 and MRE2. Ogawa, H., Johzuka, K., Nakagawa, T., Leem, S.H., Hagihara, A.H. Adv. Biophys. (1995) [Pubmed]
  7. Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation. Li, J., Hooker, G.W., Roeder, G.S. Genetics (2006) [Pubmed]
  8. Control of meiotic gene expression in Saccharomyces cerevisiae. Mitchell, A.P. Microbiol. Rev. (1994) [Pubmed]
  9. Binding of a cell-type-specific RNA splicing factor to its target regulatory sequence. Nandabalan, K., Roeder, G.S. Mol. Cell. Biol. (1995) [Pubmed]
  10. The yeast MER2 gene is required for chromosome synapsis and the initiation of meiotic recombination. Rockmill, B., Engebrecht, J.A., Scherthan, H., Loidl, J., Roeder, G.S. Genetics (1995) [Pubmed]
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