High impact information on SSO2

• SSO1 and SSO2 encode small proteins with N-terminal hydrophilic domains and C-terminal hydrophobic tails [1].
• We have used in vitro mutagenesis to obtain a temperature-sensitive SSO2 allele, sso2-1, in which a conserved arginine has been changed to a lysine [2].
• The duplicated genes SSO1 and SSO2 encode yeast homologues of syntaxin 1 and perform an essential function during fusion of secretory vesicles at the plasma membrane [2].

Regulatory relationships of SSO2

• This difference is not due to differential expression, since SSO2 expressed from the SSO1 promoter failed to restore sporulation [2].

Other interactions of SSO2

• We previously have cloned two yeast genes encoding syntaxins, SSO1 and SSO2, as suppressors of the temperature-sensitive sec1-1 mutation [3].

References