Gene Review:
STX1A - syntaxin 1A (brain)
Homo sapiens
Synonyms:
HPC-1, Neuron-specific antigen HPC-1, P35-1, STX1, SYN1A, ...
Bittner,
Bennett,
Holz,
Nirasawa,
Ito,
Fujiwara,
Seki,
Tanaka,
Akagawa,
Brandal,
Lindstedt,
Aas,
Stavnes,
Lassen,
Kapperud,
Meijer,
Thunnissen,
White,
Garnier,
Nikolic,
Tsai,
Walter,
Cleverley,
Salinas,
Wu,
Biernat,
Mandelkow,
Kim,
Pettit,
Nakayama,
Mikoshiba,
Yamamori,
Akagawa,
Tassabehji,
Metcalfe,
Karmiloff-Smith,
Carette,
Grant,
Dennis,
Reardon,
Splitt,
Read,
Donnai,
Orth,
Grif,
Fisher,
Fruth,
Tsch??pe,
Scheutz,
Dierich,
W??rzner,
Schüller,
Frankel,
Phillips,
Gonelle-Gispert,
Molinete,
Halban,
Sadoul,
- Detection of an atypical 7q11.23 deletion in Williams syndrome patients which does not include the STX1A and FZD3 genes. Botta, A., Novelli, G., Mari, A., Novelli, A., Sabani, M., Korenberg, J., Osborne, L.R., Digilio, M.C., Giannotti, A., Dallapiccola, B. J. Med. Genet. (1999)
- Expression of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, is enhanced by phorbol-ester stimulation in astroglioma: participation of the PKC signaling pathway. Nakayama, T., Mikoshiba, K., Yamamori, T., Akagawa, K. FEBS Lett. (2003)
- CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation. Kim, E., Chen, F., Wang, C.C., Harrison, L.E. Int. J. Oncol. (2006)
- Altered immunoreactivity of HPC-1/syntaxin 1A in proliferated nerve fibers in the human aganglionic colon of Hirschsprung's disease. Nirasawa, Y., Ito, Y., Fujiwara, T., Seki, N., Tanaka, H., Akagawa, K. J. Mol. Neurosci. (2001)
- Octaplex PCR and fluorescence-based capillary electrophoresis for identification of human diarrheagenic Escherichia coli and Shigella spp. Brandal, L.T., Lindstedt, B.A., Aas, L., Stavnes, T.L., Lassen, J., Kapperud, G. J. Microbiol. Methods (2007)
- Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Meijer, L., Thunnissen, A.M., White, A.W., Garnier, M., Nikolic, M., Tsai, L.H., Walter, J., Cleverley, K.E., Salinas, P.C., Wu, Y.Z., Biernat, J., Mandelkow, E.M., Kim, S.H., Pettit, G.R. Chem. Biol. (2000)
- Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation. Ferrer-Alcón, M., La Harpe, R., Guimón, J., García-Sevilla, J.A. Neuropsychopharmacology (2003)
- Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Patrick, G.N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., Tsai, L.H. Nature (1999)
- The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nikolic, M., Chou, M.M., Lu, W., Mayer, B.J., Tsai, L.H. Nature (1998)
- Evidence that syntaxin 1A is involved in storage in the secretory pathway. Bittner, M.A., Bennett, M.K., Holz, R.W. J. Biol. Chem. (1996)
- Emerging Shiga Toxin-Producing Escherichia coli Serotypes in Europe: O100:H- and O127:H40. Orth, D., Grif, K., Fisher, I., Fruth, A., Tsch??pe, H., Scheutz, F., Dierich, M.P., W??rzner, R. Curr. Microbiol. (2006)
- Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. Lin, H., Juang, J.L., Wang, P.S. J. Biol. Chem. (2004)
- Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells. Ubeda, M., Kemp, D.M., Habener, J.F. Endocrinology (2004)
- Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. Datta, R., Kojima, H., Banach, D., Bump, N.J., Talanian, R.V., Alnemri, E.S., Weichselbaum, R.R., Wong, W.W., Kufe, D.W. J. Biol. Chem. (1997)
- Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2. Nakayama, T., Fujiwara, T., Miyazawa, A., Asakawa, S., Shimizu, N., Shimizu, Y., Mikoshiba, K., Akagawa, K. Genomics (1997)
- Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms. Naren, A.P., Nelson, D.J., Xie, W., Jovov, B., Pevsner, J., Bennett, M.K., Benos, D.J., Quick, M.W., Kirk, K.L. Nature (1997)
- Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions. Naren, A.P., Quick, M.W., Collawn, J.F., Nelson, D.J., Kirk, K.L. Proc. Natl. Acad. Sci. U.S.A. (1998)
- p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. Patrick, G.N., Zhou, P., Kwon, Y.T., Howley, P.M., Tsai, L.H. J. Biol. Chem. (1998)
- Supernumerary ring chromosome 7 mosaicism: case report, investigation of the gene content, and delineation of the phenotype. Lichtenbelt, K.D., Hochstenbach, R., van Dam, W.M., Eleveld, M.J., Poot, M., Beemer, F.A. Am. J. Med. Genet. A (2005)
- Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents. Naren, A.P., Di, A., Cormet-Boyaka, E., Boyaka, P.N., McGhee, J.R., Zhou, W., Akagawa, K., Fujiwara, T., Thome, U., Engelhardt, J.F., Nelson, D.J., Kirk, K.L. J. Clin. Invest. (2000)
- Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Misura, K.M., Bock, J.B., Gonzalez, L.C., Scheller, R.H., Weis, W.I. Proc. Natl. Acad. Sci. U.S.A. (2002)
- SNAP-25/Syntaxin 1A Complex Functionally Modulates Neurotransmitter {gamma}-Aminobutyric Acid Reuptake. Fan, H.P., Fan, F.J., Bao, L., Pei, G. J. Biol. Chem. (2006)
- Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter. Lee, K.H., Kim, M.Y., Kim, D.H., Lee, Y.S. Neurochem. Res. (2004)
- The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion. McNew, J.A., Weber, T., Engelman, D.M., Söllner, T.H., Rothman, J.E. Mol. Cell (1999)
- CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex. Cormet-Boyaka, E., Di, A., Chang, S.Y., Naren, A.P., Tousson, A., Nelson, D.J., Kirk, K.L. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs. Fasshauer, D., Sutton, R.B., Brunger, A.T., Jahn, R. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells. Gonelle-Gispert, C., Molinete, M., Halban, P.A., Sadoul, K. J. Cell. Sci. (2000)
- Identification of syntaxin 1A as a novel binding protein for presenilin-1. Smith, S.K., Anderson, H.A., Yu, G., Robertson, A.G., Allen, S.J., Tyler, S.J., Naylor, R.L., Mason, G., Wilcock, G.W., Roche, P.A., Fraser, P.E., Dawbarn, D. Brain Res. Mol. Brain Res. (2000)
- Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy. Borghi, R., Giliberto, L., Assini, A., Delacourte, A., Perry, G., Smith, M.A., Strocchi, P., Zaccheo, D., Tabaton, M. Neurology (2002)
- Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability. Lau, K.F., Howlett, D.R., Kesavapany, S., Standen, C.L., Dingwall, C., McLoughlin, D.M., Miller, C.C. Mol. Cell. Neurosci. (2002)
- Interaction of Shiga toxin from Escherichia coli with human intestinal epithelial cell lines and explants: Stx2 induces epithelial damage in organ culture. Schüller, S., Frankel, G., Phillips, A.D. Cell. Microbiol. (2004)
- SNAP-25 traffics to the plasma membrane by a syntaxin-independent mechanism. Loranger, S.S., Linder, M.E. J. Biol. Chem. (2002)
- Interaction of syntaxins with the amiloride-sensitive epithelial sodium channel. Saxena, S., Quick, M.W., Tousson, A., Oh, Y., Warnock, D.G. J. Biol. Chem. (1999)
- Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A. Beckman, M.L., Bernstein, E.M., Quick, M.W. J. Neurosci. (1998)
- Escherichia coli shiga-like toxins induce apoptosis and cleavage of poly(ADP-ribose) polymerase via in vitro activation of caspases. Ching, J.C., Jones, N.L., Ceponis, P.J., Karmali, M.A., Sherman, P.M. Infect. Immun. (2002)
- G protein modulation of N-type calcium channels is facilitated by physical interactions between syntaxin 1A and Gbetagamma. Jarvis, S.E., Magga, J.M., Beedle, A.M., Braun, J.E., Zamponi, G.W. J. Biol. Chem. (2000)
- Williams syndrome: use of chromosomal microdeletions as a tool to dissect cognitive and physical phenotypes. Tassabehji, M., Metcalfe, K., Karmiloff-Smith, A., Carette, M.J., Grant, J., Dennis, N., Reardon, W., Splitt, M., Read, A.P., Donnai, D. Am. J. Hum. Genet. (1999)
- Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3. Kauppi, M., Wohlfahrt, G., Olkkonen, V.M. J. Biol. Chem. (2002)
- Regulation of the amiloride-sensitive epithelial sodium channel by syntaxin 1A. Qi, J., Peters, K.W., Liu, C., Wang, J.M., Edinger, R.S., Johnson, J.P., Watkins, S.C., Frizzell, R.A. J. Biol. Chem. (1999)
- Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis. Zhang, R., Maksymowych, A.B., Simpson, L.L. Gene (1995)