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Gene Review

Stx1a  -  syntaxin 1A (brain)

Rattus norvegicus

Synonyms: Neuron-specific antigen HPC-1, P35A, Sap, Synaptotagmin-associated 35 kDa protein, Syntaxin-1A
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Disease relevance of Stx1a


High impact information on Stx1a

  • Microinjection studies suggest that the nervous system-specific syntaxin 1A is important for calcium-regulated secretion from neuro-endocrine PC12 cells [5].
  • Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex [6].
  • The structure also indicates mechanisms that might couple the action of upstream effector proteins to conformational changes in syntaxin 1a and nSec1 that lead to core complex formation and membrane fusion [6].
  • During neuronal exocytosis, the vesicle-bound soluble NSF attachment protein (SNAP) receptor (SNARE) synaptobrevin 2 forms complexes with the plasma membrane-bound SNAREs syntaxin 1A and SNAP25 to initiate the fusion reaction [7].
  • Alteration of the kinetic properties of voltage-gated Ca(2+) channels, Ca(v)1.2 (Lc-type), Ca(v)2.2 (N type), and Ca(v)2.3 (R type), by syntaxin 1A (Syn1A) and synaptotagmin could modulate exocytosis [8].

Chemical compound and disease context of Stx1a

  • 4. In conscious rats previously exposed to 15 days hypoxia and studied under 10% O2, DMPPO (0.01, 0.05 and 0.1 mg kg(-1), i.v. bolus) caused a dose-dependent decrease in pulmonary arterial pressure (Pap) with no change in systemic artery pressure (Sap) and cardiac output [9].

Biological context of Stx1a


Anatomical context of Stx1a


Associations of Stx1a with chemical compounds


Physical interactions of Stx1a


Regulatory relationships of Stx1a


Other interactions of Stx1a


Analytical, diagnostic and therapeutic context of Stx1a


  1. Functional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion. Thomas, D.M., Elferink, L.A. J. Neurosci. (1998) [Pubmed]
  2. A late phase of exocytosis from synaptosomes induced by elevated [Ca2+]i is not blocked by Clostridial neurotoxins. Ashton, A.C., Dolly, J.O. J. Neurochem. (2000) [Pubmed]
  3. In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors. Cassone, A., De Bernardis, F., Torosantucci, A., Tacconelli, E., Tumbarello, M., Cauda, R. J. Infect. Dis. (1999) [Pubmed]
  4. High aspartyl proteinase production and vaginitis in human immunodeficiency virus-infected women. de Bernardis, F., Mondello, F., Scaravelli, G., Pachì, A., Girolamo, A., Agatensi, L., Cassone, A. J. Clin. Microbiol. (1999) [Pubmed]
  5. The syntaxin family of vesicular transport receptors. Bennett, M.K., García-Arrarás, J.E., Elferink, L.A., Peterson, K., Fleming, A.M., Hazuka, C.D., Scheller, R.H. Cell (1993) [Pubmed]
  6. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Misura, K.M., Scheller, R.H., Weis, W.I. Nature (2000) [Pubmed]
  7. SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs. Lang, T., Margittai, M., Hölzler, H., Jahn, R. J. Cell Biol. (2002) [Pubmed]
  8. Ionic dependence of Ca2+ channel modulation by syntaxin 1A. Wiser, O., Cohen, R., Atlas, D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats. Eddahibi, S., Raffestin, B., Le Monnier de Gouville, A.C., Adnot, S. Br. J. Pharmacol. (1998) [Pubmed]
  10. Munc18-dependent regulation of synaptic vesicle exocytosis by syntaxin-1A in hippocampal neurons. Mitchell, S.J., Ryan, T.A. Neuropharmacology (2005) [Pubmed]
  11. SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission. Su, Q., Mochida, S., Tian, J.H., Mehta, R., Sheng, Z.H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  12. Syntaxin 1A has a specific binding site in the H3 domain that is critical for targeting of H+-ATPase to apical membrane of renal epithelial cells. Li, G., Yang, Q., Alexander, E.A., Schwartz, J.H. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  13. Identification of syntaxin-1A sites of phosphorylation by casein kinase I and casein kinase II. Dubois, T., Kerai, P., Learmonth, M., Cronshaw, A., Aitken, A. Eur. J. Biochem. (2002) [Pubmed]
  14. Reduction of neurotransmitter release by the exogenous H3 domain peptide of HPC-1/syntaxin 1A in cultured rat hippocampal neurons. Mishima, T., Fujiwara, T., Akagawa, K. Neurosci. Lett. (2002) [Pubmed]
  15. In chromaffin cells, the mammalian Sec1p homologue is a syntaxin 1A-binding protein associated with chromaffin granules. Hodel, A., Schäfer, T., Gerosa, D., Burger, M.M. J. Biol. Chem. (1994) [Pubmed]
  16. Myosin-Va regulates exocytosis through the submicromolar Ca2+-dependent binding of syntaxin-1A. Watanabe, M., Nomura, K., Ohyama, A., Ishikawa, R., Komiya, Y., Hosaka, K., Yamauchi, E., Taniguchi, H., Sasakawa, N., Kumakura, K., Ushiki, T., Sato, O., Ikebe, M., Igarashi, M. Mol. Biol. Cell (2005) [Pubmed]
  17. Expression and functional role of syntaxin 1/HPC-1 in pancreatic beta cells. Syntaxin 1A, but not 1B, plays a negative role in regulatory insulin release pathway. Nagamatsu, S., Fujiwara, T., Nakamichi, Y., Watanabe, T., Katahira, H., Sawa, H., Akagawa, K. J. Biol. Chem. (1996) [Pubmed]
  18. Cysteine residues of SNAP-25 are required for SNARE disassembly and exocytosis, but not for membrane targeting. Washbourne, P., Cansino, V., Mathews, J.R., Graham, M., Burgoyne, R.D., Wilson, M.C. Biochem. J. (2001) [Pubmed]
  19. Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus. Zink, M., Rapp, S., Gebicke-Haerter, P.J., Henn, F.A., Thome, J. Psychopharmacology (Berl.) (2005) [Pubmed]
  20. Syntaxin 1A modulates the voltage-gated L-type calcium channel (Ca(v)1.2) in a cooperative manner. Arien, H., Wiser, O., Arkin, I.T., Leonov, H., Atlas, D. J. Biol. Chem. (2003) [Pubmed]
  21. Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions. Pabst, S., Hazzard, J.W., Antonin, W., Südhof, T.C., Jahn, R., Rizo, J., Fasshauer, D. J. Biol. Chem. (2000) [Pubmed]
  22. Evidence for SNARE zippering during Ca2+-triggered exocytosis in PC12 cells. Matos, M.F., Mukherjee, K., Chen, X., Rizo, J., Südhof, T.C. Neuropharmacology (2003) [Pubmed]
  23. Differential interaction patterns in binding assays between recombinant syntaxin 1 and synaptobrevin isoforms. Pérez-Brangulí, F., Ruiz-Montasell, B., Blasi, J. FEBS Lett. (1999) [Pubmed]
  24. Interaction of taxilin with syntaxin which does not form the SNARE complex. Nogami, S., Satoh, S., Nakano, M., Terano, A., Shirataki, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  25. The septin Sept5/CDCrel-1 competes with alpha-SNAP for binding to the SNARE complex. Beites, C.L., Campbell, K.A., Trimble, W.S. Biochem. J. (2005) [Pubmed]
  26. The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interactions. Lewis, J.L., Dong, M., Earles, C.A., Chapman, E.R. J. Biol. Chem. (2001) [Pubmed]
  27. The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1. Ohno, K., Koroll, M., El Far, O., Scholze, P., Gomeza, J., Betz, H. Mol. Cell. Neurosci. (2004) [Pubmed]
  28. SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis. Chamberlain, L.H., Burgoyne, R.D., Gould, G.W. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  29. Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins. Schiavo, G., Shone, C.C., Bennett, M.K., Scheller, R.H., Montecucco, C. J. Biol. Chem. (1995) [Pubmed]
  30. Syntaxin is efficiently excluded from sphingomyelin-enriched domains in supported lipid bilayers containing cholesterol. Saslowsky, D.E., Lawrence, J.C., Henderson, R.M., Edwardson, J.M. J. Membr. Biol. (2003) [Pubmed]
  31. Syntaxin 1A and 1B display distinct distribution patterns in the rat peripheral nervous system. Aguado, F., Majó, G., Ruiz-Montasell, B., Llorens, J., Marsal, J., Blasi, J. Neuroscience (1999) [Pubmed]
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