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Gene Review

SSO1  -  Sso1p

Saccharomyces cerevisiae S288c

Synonyms: P1405, Protein SSO1, YPL232W
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High impact information on SSO1

  • SSO1 and SSO2 encode small proteins with N-terminal hydrophilic domains and C-terminal hydrophobic tails [1].
  • A yeast strain that lacks SSO1 and carries the sso2-1 allele ceases growth and accumulates secretory vesicles at the restrictive temperature [2].
  • The same mutation was introduced into SSO1, producing the sso1-1 allele, which also has a temperature-sensitive phenotype, although less pronounced than sso2-1 [2].
  • Interestingly, among these candidates, we identified two genes, SSO1 and STU2, involved in protein transport and spindle pole body formation, respectively, suggesting puzzling connections with the translation termination process [3].
  • The GenBank Accession Nos are AF307983 (K. lactis SSO1) and AF318314 (K. lactis SEB1) [4].

Biological context of SSO1

  • Up to four- or six-fold yields of a heterologous secreted protein, Bacillus alpha-amylase, or an endogenous secreted protein, invertase, were obtained respectively when expressing either one of the SSO genes, SSO1 or SSO2, from the ADH1 promoter on a multicopy plasmid [5].
  • Western blots failed to reveal a preferential expression of Sso1p in sporulating cells, indicating that effects on gene expression are unlikely to explain why the SSO1 3'UTR is needed for sporulation [6].

Regulatory relationships of SSO1

  • This difference is not due to differential expression, since SSO2 expressed from the SSO1 promoter failed to restore sporulation [2].

Other interactions of SSO1

  • We previously have cloned two yeast genes encoding syntaxins, SSO1 and SSO2, as suppressors of the temperature-sensitive sec1-1 mutation [7].
  • Mapping of sporulation-specific functions in the yeast syntaxin gene SSO1 [6].


  1. Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport. Aalto, M.K., Ronne, H., Keränen, S. EMBO J. (1993) [Pubmed]
  2. Characterization of temperature-sensitive mutations in the yeast syntaxin 1 homologues Sso1p and Sso2p, and evidence of a distinct function for Sso1p in sporulation. Jäntti, J., Aalto, M.K., Oyen, M., Sundqvist, L., Keränen, S., Ronne, H. J. Cell. Sci. (2002) [Pubmed]
  3. Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae. Namy, O., Hatin, I., Stahl, G., Liu, H., Barnay, S., Bidou, L., Rousset, J.P. Genetics (2002) [Pubmed]
  4. Kluyveromyces lactis SSO1 and SEB1 genes are functional in Saccharomyces cerevisiae and enhance production of secreted proteins when overexpressed. Toikkanen, J.H., Sundqvist, L., Keränen, S. Yeast (2004) [Pubmed]
  5. Enhancement of protein secretion in Saccharomyces cerevisiae by overproduction of Sso protein, a late-acting component of the secretory machinery. Ruohonen, L., Toikkanen, J., Tieaho, V., Outola, M., Soderlund, H., Keranen, S. Yeast (1997) [Pubmed]
  6. Mapping of sporulation-specific functions in the yeast syntaxin gene SSO1. Oyen, M., Jäntti, J., Keränen, S., Ronne, H. Curr. Genet. (2004) [Pubmed]
  7. Mso1p: a yeast protein that functions in secretion and interacts physically and genetically with Sec1p. Aalto, M.K., Jäntti, J., Ostling, J., Keränen, S., Ronne, H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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