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Gene Review

HFI1  -  Hfi1p

Saccharomyces cerevisiae S288c

Synonyms: ADA1, GAN1, SRM12, SUP110, Transcriptional coactivator HFI1/ADA1, ...
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High impact information on HFI1

  • We thus identified ADA1, ADA2, and ADA3 [1].
  • The locations of two histone fold-containing core subunits, Spt7 and Ada1, are consistent with their role in providing a SAGA-specific interface with the Tafs [2].
  • A proteomic approach led to the identification of an orthologue of the yeast protein Ada1 and the novel protein encoded by CG4448, referred to as WDA (will decrease acetylation) [3].
  • Furthermore, ADA1 interacts with the other ADAs in the ADA/GCN5 complex as demonstrated by partial purification of the complex and immunoprecipitation experiments [4].
  • We have identified a high copy suppressor of the TAF68/61 mutation, TSG2, that has sequence similarity to a region of the SAGA subunit Ada1 [5].

Biological context of HFI1


Physical interactions of HFI1

  • Ada1/Gan1p thus represents the first reported case of an accessory protein (a co-activator) linking the GATA-binding proteins Gln3p and Nil1p, mediating nitrogen-regulated transcription, to the basal transcription machinery [7].

Other interactions of HFI1

  • These two genes are NET1 and HFI1 which mediate important regulatory protein-protein interactions in the yeast cell [6].
  • Complex integrity depends on three core subunits, Spt7, Spt20, and Ada1 [8].
  • We found that GAN1 is identical to ADA1, which encodes a component of the ADA/GCN5 co-activator complex [7].
  • We show that Gan1p is in fact involved in Gln3p- and Nil1p-dependent transcription [7].


  1. Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains. Berger, S.L., Piña, B., Silverman, N., Marcus, G.A., Agapite, J., Regier, J.L., Triezenberg, S.J., Guarente, L. Cell (1992) [Pubmed]
  2. Molecular architecture of the S. cerevisiae SAGA complex. Wu, P.Y., Ruhlmann, C., Winston, F., Schultz, P. Mol. Cell (2004) [Pubmed]
  3. The Essential Gene wda Encodes a WD40 Repeat Subunit of Drosophila SAGA Required for Histone H3 Acetylation. Guelman, S., Suganuma, T., Florens, L., Weake, V., Swanson, S.K., Washburn, M.P., Abmayr, S.M., Workman, J.L. Mol. Cell. Biol. (2006) [Pubmed]
  4. ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3. Horiuchi, J., Silverman, N., Piña, B., Marcus, G.A., Guarente, L. Mol. Cell. Biol. (1997) [Pubmed]
  5. Identification of a yeast transcription factor IID subunit, TSG2/TAF48. Reese, J.C., Zhang, Z., Kurpad, H. J. Biol. Chem. (2000) [Pubmed]
  6. NET1 and HFI1 genes of yeast mediate both chromosome maintenance and mitochondrial rho(-) mutagenesis. Koltovaya, N.A., Guerasimova, A.S., Tchekhouta, I.A., Devin, A.B. Yeast (2003) [Pubmed]
  7. A co-activator of nitrogen-regulated transcription in Saccharomyces cerevisiae. Soussi-Boudekou, S., André, B. Mol. Microbiol. (1999) [Pubmed]
  8. Analysis of Spt7 function in the Saccharomyces cerevisiae SAGA coactivator complex. Wu, P.Y., Winston, F. Mol. Cell. Biol. (2002) [Pubmed]
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