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Gene Review

HRR25  -  Hrr25p

Saccharomyces cerevisiae S288c

Synonyms: Casein kinase I homolog HRR25, YPL204W
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High impact information on HRR25

  • Taken together, the hrr25 mutant phenotypes and the features of the gene product indicate that HRR25 is a distinctive member of the protein kinase superfamily [1].
  • The NH2-terminus of HRR25 contains the hallmark features of protein kinases, whereas the COOH-terminus is rich in proline and glutamine [1].
  • Homozygotes of hrr25-1 were unable to sporulate and disruption and deletion of HRR25 interfered with mitotic and meiotic cell division [1].
  • The amino acid sequence identifies the CKI as the alpha-CKI isoform, which is 62% identical to the HRR25 protein kinase [2].
  • This localization suggests that alpha-CKI, like HRR25, plays a role in the segregation of chromosomes during mitosis and may be cell cycle-regulated both in humans and in yeast [2].

Biological context of HRR25


Other interactions of HRR25

  • This is most evident for yeast genes CBK1, HRR25, and SNF1 and the kinase family S6K [4].
  • RST2 turned out to be identical to HRR25, a gene encoding a dual-specificity casein kinase I in yeast [5].
  • Single-copy complementation identified HRR25, which codes for casein kinase I (CKI), as KTI14 [6].


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