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Gene Review

NAB3  -  Nab3p

Saccharomyces cerevisiae S288c

Synonyms: HMD1, Nuclear polyadenylated RNA-binding protein 3, YPL190C
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High impact information on NAB3

  • The RNA-binding protein Nab3, the putative RNA helicase Sen1, and the intact C-terminal domain of pol II are also required for efficient response to the element [1].
  • Yeast RNA binding proteins Nrd1 and Nab3 direct termination of sn/snoRNAs and recently have also been implicated in premature transcription termination of the NRD1 gene [2].
  • Mutation of Nrd1 and Nab3 binding sites within the NRD1 mRNA leads to a relative increase in Pol II occupancy of downstream sequences [3].
  • Our results suggest an important role for the Nrd1p-Nab3p pathway in the control of gene expression throughout the genome [4].
  • We identified NAB3 as a dosage suppressor of rtf1 [5].

Biological context of NAB3


Regulatory relationships of NAB3

  • Temperature-sensitive alleles of NAB3 are suppressed by deletion of CTK1, a kinase that has been shown to phosphorylate the CTD and increase elongation efficiency in vitro [7].
  • In this paper, we show that NRD1 expression is regulated by Nrd1- and Nab3-directed premature termination [3].

Other interactions of NAB3

  • The present work demonstrates genetic and physical interactions among Nrd1p, the pol II CTD, Nab3p, and the CTD kinase CTDK-I [7].
  • Nab1p, Nab2p, and Nab3p were isolated by a method which uses UV light to cross-link proteins directly bound to poly(A)+ RNA in vivo [6].
  • Overproduction of HMD1 results in a relatively specific reduction in the level of the CLN3 or CLN3-2 transcript [8].

Analytical, diagnostic and therapeutic context of NAB3

  • Dissection of a CUT terminator reveals a minimal element sufficient for Nrd1- and Nab3-directed termination [2].


  1. RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts. Steinmetz, E.J., Conrad, N.K., Brow, D.A., Corden, J.L. Nature (2001) [Pubmed]
  2. Termination of Cryptic Unstable Transcripts Is Directed by Yeast RNA-Binding Proteins Nrd1 and Nab3. Arigo, J.T., Eyler, D.E., Carroll, K.L., Corden, J.L. Mol. Cell (2006) [Pubmed]
  3. Regulation of yeast NRD1 expression by premature transcription termination. Arigo, J.T., Carroll, K.L., Ames, J.M., Corden, J.L. Mol. Cell (2006) [Pubmed]
  4. Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance. Thiebaut, M., Kisseleva-Romanova, E., Rougemaille, M., Boulay, J., Libri, D. Mol. Cell (2006) [Pubmed]
  5. A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation. Sheldon, K.E., Mauger, D.M., Arndt, K.M. Mol. Cell (2005) [Pubmed]
  6. Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. Wilson, S.M., Datar, K.V., Paddy, M.R., Swedlow, J.R., Swanson, M.S. J. Cell Biol. (1994) [Pubmed]
  7. A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II. Conrad, N.K., Wilson, S.M., Steinmetz, E.J., Patturajan, M., Brow, D.A., Swanson, M.S., Corden, J.L. Genetics (2000) [Pubmed]
  8. Dosage suppressors of the dominant G1 cyclin mutant CLN3-2: identification of a yeast gene encoding a putative RNA/ssDNA binding protein. Sugimoto, K., Matsumoto, K., Kornberg, R.D., Reed, S.I., Wittenberg, C. Mol. Gen. Genet. (1995) [Pubmed]
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