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Gene Review

DBF20  -  serine/threonine-protein kinase DBF20

Saccharomyces cerevisiae S288c

Synonyms: Serine/threonine-protein kinase DBF20, YPR111W
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High impact information on DBF20

  • Thus, Dbf2/Dbf20 kinase activity is precisely regulated in the cell cycle by a post-translational mechanism and phosphorylates its target substrates for an event that occurs during anaphase and/or telophase [1].
  • Relocalization of these proteins from spindle pole bodies to mother daughter neck seems to be necessary for this role because cdc15-2 mutant cells, though capable of exiting mitosis at semipermissive temperature, are unable to localize Dbf2 (and Dbf20) to the "neck" and fail to undergo cytokinesis [2].
  • Here we present genetic evidence that nonfunctional mutant Dbf2 protein blocks the function of Dbf20 protein by sequestering a common interacting protein encoded by SPO12 [3].

Biological context of DBF20


Associations of DBF20 with chemical compounds

  • The kinase activity is specific for serine/threonine residues and Dbf2 accounts for the bulk of the activity, with Dbf20 playing a minor role [1].

Other interactions of DBF20


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