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Gene Review

BET2  -  Bet2p

Saccharomyces cerevisiae S288c

Synonyms: GGTase-II-beta, Geranylgeranyl transferase type II subunit beta, Geranylgeranyl transferase type-2 subunit beta, P9705.12, PGGT, ...
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High impact information on BET2

  • Therefore MAD2 and BET2 gene products may physically interact to form a geranylgeranyl transferase complex [1].
  • We have shown that Bet2p is a component of the yeast GGTase-II (refs 6, 12) that geranylgeranylates Ypt1p, a small GTP-binding protein that mediates transport from the endoplasmic reticulum to the Golgi complex [2].
  • DNA sequence analysis has revealed that Bet2 is homologous to Dpr1 (Ram1), an essential component of a protein prenyltransferase that modifies Ras, enabling it to attach to membranes [3].
  • We propose that Bet2 modifies Ypt1 and Sec4 in an analogous manner [3].
  • The new mutants, bet1 and bet2, are temperature sensitive for growth and protein transport [4].

Biological context of BET2

  • Comparisons of the amino acid sequences suggest that the proteins encoded by the Saccharomyces cerevisiae genes MAD2 and BET2 are the yeast counterparts of the mammalian Rab GG transferase alpha and beta subunits, respectively [5].
  • Mutations in the catalytic subunits of the yeast GGTase-II (Bet2p/Mad2p) disrupt the membrane attachment of Ypt1p and Sec4p and this in turn blocks membrane traffic [6].

Associations of BET2 with chemical compounds


Other interactions of BET2

  • An analysis of BET1, BET2, and BOS1. Three factors mediating ER to Golgi transport in yeast [7].


  1. The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase. Li, R., Havel, C., Watson, J.A., Murray, A.W. Nature (1993) [Pubmed]
  2. Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p. Jiang, Y., Rossi, G., Ferro-Novick, S. Nature (1993) [Pubmed]
  3. Dependence of Ypt1 and Sec4 membrane attachment on Bet2. Rossi, G., Yu, J.A., Newman, A.P., Ferro-Novick, S. Nature (1991) [Pubmed]
  4. Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection. Newman, A.P., Ferro-Novick, S. J. Cell Biol. (1987) [Pubmed]
  5. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. Armstrong, S.A., Seabra, M.C., Südhof, T.C., Goldstein, J.L., Brown, M.S. J. Biol. Chem. (1993) [Pubmed]
  6. Identification of yeast component A: reconstitution of the geranylgeranyltransferase that modifies Ypt1p and Sec4p. Jiang, Y., Ferro-Novick, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. An analysis of BET1, BET2, and BOS1. Three factors mediating ER to Golgi transport in yeast. Ferro-Novick, S., Newman, A.P., Groesch, M., Ruohola, H., Rossi, G., Graf, J., Shim, J. Cell Biophys. (1991) [Pubmed]
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