Gene Review:
MAD2 - spindle checkpoint protein MAD2
Saccharomyces cerevisiae S288c
Synonyms:
J1256, Mitotic MAD2 protein, Mitotic spindle checkpoint component MAD2, YJL030W
- Identification of a human mitotic checkpoint gene: hsMAD2. Li, Y., Benezra, R. Science (1996)
- Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function. Iwanaga, Y., Kasai, T., Kibler, K., Jeang, K.T. J. Biol. Chem. (2002)
- The Origin Recognition Complex Functions in Sister-Chromatid Cohesion in Saccharomyces cerevisiae. Shimada, K., Gasser, S.M. Cell (2007)
- How do so few control so many? Nasmyth, K. Cell (2005)
- The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes. Cheslock, P.S., Kemp, B.J., Boumil, R.M., Dawson, D.S. Nat. Genet. (2005)
- The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase. Li, R., Havel, C., Watson, J.A., Murray, A.W. Nature (1993)
- The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Chen, R.H., Brady, D.M., Smith, D., Murray, A.W., Hardwick, K.G. Mol. Biol. Cell (1999)
- Saccharomyces cerevisiae BUB2 prevents mitotic exit in response to both spindle and kinetochore damage. Krishnan, R., Pangilinan, F., Lee, C., Spencer, F. Genetics (2000)
- Ran GTPase regulates Mad2 localization to the nuclear pore complex. Quimby, B.B., Arnaoutov, A., Dasso, M. Eukaryotic Cell (2005)
- Bipolar orientation of chromosomes in Saccharomyces cerevisiae is monitored by Mad1 and Mad2, but not by Mad3. Lee, M.S., Spencer, F.A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The spindle checkpoint of Saccharomyces cerevisiae responds to separable microtubule-dependent events. Daum, J.R., Gomez-Ospina, N., Winey, M., Burke, D.J. Curr. Biol. (2000)
- Control of localization of a spindle checkpoint protein, Mad2, in fission yeast. Ikui, A.E., Furuya, K., Yanagida, M., Matsumoto, T. J. Cell. Sci. (2002)
- Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae. Poddar, A., Stukenberg, P.T., Burke, D.J. Eukaryotic Cell (2005)
- Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p. Jiang, Y., Rossi, G., Ferro-Novick, S. Nature (1993)
- Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae. Nezi, L., Rancati, G., De Antoni, A., Pasqualato, S., Piatti, S., Musacchio, A. J. Cell Biol. (2006)
- The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. Iouk, T., Kerscher, O., Scott, R.J., Basrai, M.A., Wozniak, R.W. J. Cell Biol. (2002)
- Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2. Fraschini, R., Formenti, E., Lucchini, G., Piatti, S. J. Cell Biol. (1999)
- Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae. Yoshida, S., Asakawa, K., Toh-e, A. Curr. Biol. (2002)
- Mutations in the yeast cyclin-dependent kinase Cdc28 reveal a role in the spindle assembly checkpoint. Kitazono, A.A., Garza, D.A., Kron, S.J. Mol. Genet. Genomics (2003)
- Suppression of a conditional mutation in alpha-tubulin by overexpression of two checkpoint genes. Guénette, S., Magendantz, M., Solomon, F. J. Cell. Sci. (1995)
- Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner. Millband, D.N., Hardwick, K.G. Mol. Cell. Biol. (2002)
- The role of Cdc55 in the spindle checkpoint is through regulation of mitotic exit in Saccharomyces cerevisiae. Yellman, C.M., Burke, D.J. Mol. Biol. Cell (2006)
- The role of Cdh1p in maintaining genomic stability in budding yeast. Ross, K.E., Cohen-Fix, O. Genetics (2003)
- The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. Topper, L.M., Campbell, M.S., Tugendreich, S., Daum, J.R., Burke, D.J., Hieter, P., Gorbsky, G.J. Cell Cycle (2002)
- Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Luo, X., Fang, G., Coldiron, M., Lin, Y., Yu, H., Kirschner, M.W., Wagner, G. Nat. Struct. Biol. (2000)
- Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation. Zhang, Y., Lees, E. Mol. Cell. Biol. (2001)