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Gene Review

CPR2  -  peptidylprolyl isomerase CPR2

Saccharomyces cerevisiae S288c

Synonyms: CRG, CYP2, Cyclophilin B, Cyclophilin-related protein, PPIase B, ...
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Disease relevance of CPR2


High impact information on CPR2

  • The two enzymes, designated CPR1 and CPR2, are 80% identical in amino acid sequence with one another and about 75% identical with CPRs from several other plant species [3].
  • Sequence comparisons of the CyPB proteins show a central, 165-amino acid peptidyl-prolyl isomerase and cyclosporin A-binding domain, flanked by variable N-terminal and C-terminal domains [4].
  • Transcripts for the three poplar CPR genes were present ubiquitously in all tissues examined, but CPR2 showed highest expression in young leaf tissue [5].
  • Deduced CPR2 and CPR3 amino acid sequences were 91% identical, but encoded isoforms divergent from CPR1 (72% identity) [5].
  • As with CYP1, genomic disruption of CYP2 had no effect on haploid cell viability [1].

Biological context of CPR2

  • Whereas cells containing a genomic disruption of CYP1 exhibited a CsA-resistant phenotype, genomic disruption of CYP2 had no effect on CsA sensitivity [1].

Associations of CPR2 with chemical compounds


  1. The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence. Koser, P.L., Bergsma, D.J., Cafferkey, R., Eng, W.K., McLaughlin, M.M., Ferrara, A., Silverman, C., Kasyan, K., Bossard, M.J., Johnson, R.K. Gene (1991) [Pubmed]
  2. Kidney androgen-regulated protein interacts with cyclophilin B and reduces cyclosporine A-mediated toxicity in proximal tubule cells. Cebrián, C., Aresté, C., Nicolás, A., Olivé, P., Carceller, A., Piulats, J., Meseguer, A. J. Biol. Chem. (2001) [Pubmed]
  3. Differentially regulated NADPH:cytochrome P450 oxidoreductases in parsley. Koopmann, E., Hahlbrock, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Price, E.R., Zydowsky, L.D., Jin, M.J., Baker, C.H., McKeon, F.D., Walsh, C.T. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Cloning, functional expression, and subcellular localization of multiple NADPH-cytochrome P450 reductases from hybrid poplar. Ro, D.K., Ehlting, J., Douglas, C.J. Plant Physiol. (2002) [Pubmed]
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