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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KOG1  -  Kog1p

Saccharomyces cerevisiae S288c

Synonyms: H9998.14, Kontroller of growth protein 1, LAS24, Local anesthetic-sensitive protein 24, TORC1 subunit KOG1, ...
 
 
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High impact information on KOG1

  • Biochemical and genetic analyses of these mutant forms of Tor1p support a model wherein functional interactions between the FRB and kinase domains, as well as between the FRB domain and the TORC1 component Kog1p, regulate TOR activity as well as contribute to the mechanism of caffeine resistance [1].
  • LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast [2].
  • These observations along with the facts that tetracaine and high temperature differentially affected the las24-1 mutant suggest that Las24p/Kog1p is not a target of tetracaine and that the tetracaine-sensitive step may be one of downstream branches of the TORC1 pathway [2].
  • Las24p/Kog1p is a widely conserved TOR binding protein containing the NRC domain, HEAT repeats and WD-40 repeats, but its function remains unknown [2].
 

Associations of KOG1 with chemical compounds

  • In contrast, we find that Kog1, the yeast homologue of the mammalian Tor regulatory protein Raptor, interacts preferentially with Tor1p [3].

References

  1. Caffeine Targets TOR Complex I and Provides Evidence for a Regulatory Link between the FRB and Kinase Domains of Tor1p. Reinke, A., Chen, J.C., Aronova, S., Powers, T. J. Biol. Chem. (2006) [Pubmed]
  2. LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. Araki, T., Uesono, Y., Oguchi, T., Toh-E, A. Genes Genet. Syst. (2005) [Pubmed]
  3. Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Wedaman, K.P., Reinke, A., Anderson, S., Yates, J., McCaffery, J.M., Powers, T. Mol. Biol. Cell (2003) [Pubmed]
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