Gene Review:
CRTC1 - CREB regulated transcription coactivator 1
Homo sapiens
Synonyms:
FLJ14027, KIAA0616, MECT1, TORC-1, TORC1, ...
- TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. Siu, Y.T., Chin, K.T., Siu, K.L., Yee Wai Choy, E., Jeang, K.T., Jin, D.Y. J. Virol. (2006)
- Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. Behboudi, A., Winnes, M., Gorunova, L., van den Oord, J.J., Mertens, F., Enlund, F., Stenman, G. Genes Chromosomes Cancer (2005)
- mTOR Pathway as a Target in Tissue Hypertrophy. Lee, C.H., Inoki, K., Guan, K.L. Annu. Rev. Pharmacol. Toxicol. (2007)
- TORCs rev up gluconeogenesis. Patil, S., Unterman, T.G. Cell metabolism. (2005)
- A study on the relationship between solid cell nests and mucoepidermoid carcinoma of the thyroid. Harach, H.R. Histopathology (1985)
- Acute and maintenance ECT with flupenthixol in refractory schizophrenia: sustained improvements in psychopathology, quality of life, and social outcomes. Chanpattana, W., Kramer, B.A. Schizophr. Res. (2003)
- A seasonal schedule for maintenance ECT. Kramer, B.A. The journal of ECT. (1999)
- A review of continuation and maintenance electroconvulsive therapy. Rabheru, K., Persad, E. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (1997)
- SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity. Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J., Su, B. Cell (2006)
- TOR signaling in growth and metabolism. Wullschleger, S., Loewith, R., Hall, M.N. Cell (2006)
- t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Tonon, G., Modi, S., Wu, L., Kubo, A., Coxon, A.B., Komiya, T., O'Neil, K., Stover, K., El-Naggar, A., Griffin, J.D., Kirsch, I.R., Kaye, F.J. Nat. Genet. (2003)
- Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. Wu, L., Liu, J., Gao, P., Nakamura, M., Cao, Y., Shen, H., Griffin, J.D. EMBO J. (2005)
- Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J.M., Orth, A.P., Miraglia, L., Meltzer, J., Garza, D., Chirn, G.W., McWhinnie, E., Cohen, D., Skelton, J., Terry, R., Yu, Y., Bodian, D., Buxton, F.P., Zhu, J., Song, C., Labow, M.A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. Coxon, A., Rozenblum, E., Park, Y.S., Joshi, N., Tsurutani, J., Dennis, P.A., Kirsch, I.R., Kaye, F.J. Cancer Res. (2005)
- Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Enlund, F., Behboudi, A., Andrén, Y., Oberg, C., Lendahl, U., Mark, J., Stenman, G. Exp. Cell Res. (2004)
- TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Yang, Q., Inoki, K., Kim, E., Guan, K.L. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Complexity of the TOR signaling network. Inoki, K., Guan, K.L. Trends Cell Biol. (2006)
- Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation. Komiya, T., Park, Y., Modi, S., Coxon, A.B., Oh, H., Kaye, F.J. Oncogene (2006)
- Caffeine Targets TOR Complex I and Provides Evidence for a Regulatory Link between the FRB and Kinase Domains of Tor1p. Reinke, A., Chen, J.C., Aronova, S., Powers, T. J. Biol. Chem. (2006)
- Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Avruch, J., Hara, K., Lin, Y., Liu, M., Long, X., Ortiz-Vega, S., Yonezawa, K. Oncogene (2006)
- Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. Katoh, Y., Takemori, H., Lin, X.Z., Tamura, M., Muraoka, M., Satoh, T., Tsuchiya, Y., Min, L., Doi, J., Miyauchi, A., Witters, L.A., Nakamura, H., Okamoto, M. FEBS J. (2006)
- Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1{alpha} transcription and mitochondrial biogenesis in muscle cells. Wu, Z., Huang, X., Feng, Y., Handschin, C., Feng, Y., Gullicksen, P.S., Bare, O., Labow, M., Spiegelman, B., Stevenson, S.C. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Liu, L., Li, F., Cardelli, J.A., Martin, K.A., Blenis, J., Huang, S. Oncogene (2006)
- Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex. Rocha, A.S., Soares, P., Machado, J.C., Máximo, V., Fonseca, E., Franssila, K., Sobrinho-Simões, M. Virchows Arch. (2002)
- ECT in the elderly. Greenberg, R.M. New directions for mental health services. (1997)