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Gene Review:

MET6 - 5-methyltetrahydropteroyltriglutamate...

Saccharomyces cerevisiae S288c

Synonyms: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Delta-P8 protein, Methionine synthase, vitamin-B12 independent isozyme, YER091C

Csaikl, U. et al., Eichel, J. et al., Burt, E.T. et al., Kallal, L.A. et al.

Burt, O'Connor, Larsen,

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Disease relevance of MET6

We describe the cloning, expression and characterization of a methionine synthase from the higher plant Catharanthus roseus. cDNAs were identified that encoded a protein of 85 kDa sharing 50% identify with the cobalamin-independent methionine synthase from Escherichia coli (MetE) and 41% identity with a partial sequence of a yeast homolog of MetE [1].

High impact information on MET6

A yeast DNA fragment complementing the met6 mutation in yeast (Saccharomyces cerevisiae) was cloned in a shuttle vector, Yep13, by transforming a yeast host with plasmid DNA prepared from yeast gene bank CV13 of K [2].
SPR6 is located on chromosome V, 14.4 centimorgans centromere-distal to MET6 [3].
The results of this study suggest that a cobalamin-independent methionine synthase homolog is inducible by heat and estrogen in C. albicans [4].

Analytical, diagnostic and therapeutic context of MET6

Molecular cloning and characterization of the MET6 gene of Saccharomyces cerevisiae [2].
A 2.5-kb transcript is found both in wild-type (wt) and met6 yeast strains by Northern blotting experiments, indicating that the mutation acts at posttranscriptional level [2].

References

Vitamin-B12-independent methionine synthase from a higher plant (Catharanthus roseus). Molecular characterization, regulation, heterologous expression, and enzyme properties. Eichel, J., González, J.C., Hotze, M., Matthews, R.G., Schröder, J. Eur. J. Biochem. (1995) [Pubmed]
Molecular cloning and characterization of the MET6 gene of Saccharomyces cerevisiae. Csaikl, U., Csaikl, F. Gene (1986) [Pubmed]
Functional analysis of the sporulation-specific SPR6 gene of Saccharomyces cerevisiae. Kallal, L.A., Bhattacharyya, M., Grove, S.N., Iannacone, R.F., Pugh, T.A., Primerano, D.A., Clancy, M.J. Curr. Genet. (1990) [Pubmed]
Isolation and identification of a 92-kDa stress induced protein from Candida albicans. Burt, E.T., O'Connor, C., Larsen, B. Mycopathologia (1999) [Pubmed]

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ATMS1	Arabidopsis thaliana
MS2	Arabidopsis thaliana
AGOS_ABR212C	Ashbya gossypii ATCC 10895
KLLA0E20065g	Kluyveromyces lactis NRRL Y-1140
MGG_06712	Magnaporthe oryzae 70-15
NCU06512	Neurospora crassa OR74A
Os12g0623900	Oryza sativa Japonica Group
Os12g0624000	Oryza sativa Japonica Group
met26	Schizosaccharomyces pombe 972h-

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