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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Catharanthus


High impact information on Catharanthus

  • Here we report that auxin can generate transient changes in inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol bisphosphate (InsP2) within minutes in Catharanthus roseus cells arrested in G1 [2].
  • The gene for ORCA3, a jasmonate-responsive APETALA2 (AP2)-domain transcription factor from Catharanthus roseus, was isolated by transferred DNA activation tagging [3].
  • These octadecanoid-derivative responsive Catharanthus AP2-domain (ORCA) proteins bind in a sequence-specific manner the JA- and elicitor-responsive element [4].
  • The intracellular location of a cytochrome P-450-dependent monoterpene hydroxylase from the higher plant, Catharanthus roseus, has been investigated [5].
  • Although genetic approaches are difficult for most plant species, promoter studies of single-pathway genes and T-DNA activation tagging are feasible alternative approaches for isolating transcription factors, as illustrated for terpenoid indole alkaloid biosynthesis in Catharanthus roseus [6].

Chemical compound and disease context of Catharanthus


Biological context of Catharanthus


Anatomical context of Catharanthus


Associations of Catharanthus with chemical compounds


Gene context of Catharanthus


Analytical, diagnostic and therapeutic context of Catharanthus


  1. Molecular characterization of recombinant T1, a non-allergenic periwinkle (Catharanthus roseus) protein, with sequence similarity to the Bet v 1 plant allergen family. Laffer, S., Hamdi, S., Lupinek, C., Sperr, W.R., Valent, P., Verdino, P., Keller, W., Grote, M., Hoffmann-Sommergruber, K., Scheiner, O., Kraft, D., Rideau, M., Valenta, R. Biochem. J. (2003) [Pubmed]
  2. Auxin induces rapid changes in phosphatidylinositol metabolites. Ettlinger, C., Lehle, L. Nature (1988) [Pubmed]
  3. ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. van der Fits, L., Memelink, J. Science (2000) [Pubmed]
  4. A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2. Menke, F.L., Champion, A., Kijne, J.W., Memelink, J. EMBO J. (1999) [Pubmed]
  5. Subcellular localization of a cytochrome P-450-dependent monogenase in vesicles of the higher plant Catharanthus roseus. Madyastha, K.M., Ridgway, J.E., Dwyer, J.G., Coscia, C.J. J. Cell Biol. (1977) [Pubmed]
  6. Transcription factors: tools to engineer the production of pharmacologically active plant metabolites. Gantet, P., Memelink, J. Trends Pharmacol. Sci. (2002) [Pubmed]
  7. Vitamin-B12-independent methionine synthase from a higher plant (Catharanthus roseus). Molecular characterization, regulation, heterologous expression, and enzyme properties. Eichel, J., González, J.C., Hotze, M., Matthews, R.G., Schröder, J. Eur. J. Biochem. (1995) [Pubmed]
  8. A novel cis-acting element in promoters of plant B-type cyclin genes activates M phase-specific transcription. Ito, M., Iwase, M., Kodama, H., Lavisse, P., Komamine, A., Nishihama, R., Machida, Y., Watanabe, A. Plant Cell (1998) [Pubmed]
  9. Purification, characterization, and kinetic analysis of a 2-oxoglutarate-dependent dioxygenase involved in vindoline biosynthesis from Catharanthus roseus. De Carolis, E., De Luca, V. J. Biol. Chem. (1993) [Pubmed]
  10. Novel type of receptor-like protein kinase from a higher plant (Catharanthus roseus). cDNA, gene, intramolecular autophosphorylation, and identification of a threonine important for auto- and substrate phosphorylation. Schulze-Muth, P., Irmler, S., Schröder, G., Schröder, J. J. Biol. Chem. (1996) [Pubmed]
  11. Identification of a novel S-phase-specific gene during the cell cycle in synchronous cultures of Catharanthus roseus cells. Ito, M., Kodama, H., Komamine, A. Plant J. (1991) [Pubmed]
  12. Elicitor-responsive promoter regions in the tryptophan decarboxylase gene from Catharanthus roseus. Ouwerkerk, P.B., Memelink, J. Plant Mol. Biol. (1999) [Pubmed]
  13. Letter: Biosynthesis of the indole alkaloids. A cell-free system from Catharanthus roseus. Scott, A.I., Lee, S.L. J. Am. Chem. Soc. (1975) [Pubmed]
  14. Purification and properties of strictosidine synthetase (an enzyme condensing tryptamine and secologanin) from Catharanthus roseus cultured cells. Mizukami, H., Nordlöv, H., Lee, S.L., Scott, A.I. Biochemistry (1979) [Pubmed]
  15. Phosphate uptake across the tonoplast of intact vacuoles isolated from suspension-cultured cells of Catharanthus roseus (L.) G. Don. Massonneau, A., Martinoia, E., Dietz, K.J., Mimura, T. Planta (2000) [Pubmed]
  16. Quantitation of the delivery of liposome contents into plant protoplasts. Cutler, A.J., Constabel, F., Kurz, W.G., Shargool, P.D. Anal. Biochem. (1984) [Pubmed]
  17. Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase over-expressing transgenic cell line T22 of Catharanthus roseus. Whitmer, S., van der Heijden, R., Verpoorte, R. J. Biotechnol. (2002) [Pubmed]
  18. Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: comparison with animal dopa decarboxylases. De Luca, V., Marineau, C., Brisson, N. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  19. Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement. Arigoni, D., Sagner, S., Latzel, C., Eisenreich, W., Bacher, A., Zenk, M.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  20. Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Irmler, S., Schröder, G., St-Pierre, B., Crouch, N.P., Hotze, M., Schmidt, J., Strack, D., Matern, U., Schröder, J. Plant J. (2000) [Pubmed]
  21. Flavonoid hydroxylase from Catharanthus roseus: cDNA, heterologous expression, enzyme properties and cell-type specific expression in plants. Kaltenbach, M., Schröder, G., Schmelzer, E., Lutz, V., Schröder, J. Plant J. (1999) [Pubmed]
  22. Deduced amino acid sequence of bovine aromatic L-amino acid decarboxylase: homology to other decarboxylases. Kang, U.J., Joh, T.H. Brain Res. Mol. Brain Res. (1990) [Pubmed]
  23. Cytochrome P450 2D6 (CYP2D6) inhibitory constituents of Catharanthus roseus. Usia, T., Watabe, T., Kadota, S., Tezuka, Y. Biol. Pharm. Bull. (2005) [Pubmed]
  24. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Usia, T., Iwata, H., Hiratsuka, A., Watabe, T., Kadota, S., Tezuka, Y. Phytomedicine (2006) [Pubmed]
  25. Isolation of cytochrome P-450 cDNA clones from the higher plant Catharanthus roseus by a PCR strategy. Meijer, A.H., Souer, E., Verpoorte, R., Hoge, J.H. Plant Mol. Biol. (1993) [Pubmed]
  26. Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels. Hughes, E.H., Hong, S.B., Gibson, S.I., Shanks, J.V., San, K.Y. Biotechnol. Bioeng. (2004) [Pubmed]
  27. Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Geerlings, A., Ibañez, M.M., Memelink, J., van Der Heijden, R., Verpoorte, R. J. Biol. Chem. (2000) [Pubmed]
  28. Does a proton-pumping ATPase exist in the tonoplast? Dupaix, A., Hill, M., Volfin, P., Arrio, B. Biochimie (1986) [Pubmed]
  29. Direct fluorometry of phase-extracted tryptamine-based fast quantitative assay of L-tryptophan decarboxylase from Catharanthus roseus leaf. Sangwan, R.S., Mishra, S., Kumar, S. Anal. Biochem. (1998) [Pubmed]
  30. Purification and characterization of acetylcoenzyme A: deacetylvindoline 4-O-acetyltransferase from Catharanthus roseus. Power, R., Kurz, W.G., De Luca, V. Arch. Biochem. Biophys. (1990) [Pubmed]
  31. Effect of culture process on alkaloid production by Catharanthus roseus cells. II. Immobilized cultures. Tom, R., Jardin, B., Chavarie, C., Rho, D., Archambault, J. J. Biotechnol. (1991) [Pubmed]
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