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Gene Review:

EIF4EBP3 - eukaryotic translation initiation factor...

Homo sapiens

Synonyms: 4E-BP3, 4EBP3, Eukaryotic translation initiation factor 4E-binding protein 3, eIF4E-binding protein 3

Poulin, F. et al., Wang, X. et al., Kleijn, M. et al., Tee, A.R. et al.

Kleijn, Scheper, Wilson, Tee, Proud,

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High impact information on EIF4EBP3

However, in 4E-BP3, replacement of the alanine at the position corresponding to S112 by serine or glutamate did not confer the ability to be released from eIF4E in response to insulin [1].
Insulin increased the phosphorylation of 4E-BP3 but not sufficiently to cause its release from eIF4E [2].
A gene fusion similar to that of MASK and EIF4EBP3 has been reported only once in mammals for the UEV1-Kua transcript [3].
EIF4EBP3 is located on human chromosome 5q31.3 and comprises three exons (A, B, and C) and two introns [3].
Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK [3].

Biological context of EIF4EBP3

The simultaneous exploitation of both mechanisms underscores the flexibility of mammalian genomes and has important implications for the functional analysis of 4E-BP3 and MASK [3].
Surprisingly, the open reading frame of the MASK-BP3 transcript is different from that of 4E-BP3, which indicates that exon B is translated using an alternative reading frame [3].

Anatomical context of EIF4EBP3

We show that 4E-BP3 is present in the nucleus as well as in the cytoplasm in primary T cells, HEK293 cells and HeLa cells [4].

References

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Wang, X., Li, W., Parra, J.L., Beugnet, A., Proud, C.G. Mol. Cell. Biol. (2003) [Pubmed]
Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Tee, A.R., Proud, C.G. Mol. Cell. Biol. (2002) [Pubmed]
Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. Poulin, F., Brueschke, A., Sonenberg, N. J. Biol. Chem. (2003) [Pubmed]
Localisation and regulation of the eIF4E-binding protein 4E-BP3. Kleijn, M., Scheper, G.C., Wilson, M.L., Tee, A.R., Proud, C.G. FEBS Lett. (2002) [Pubmed]

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EIF4EBP3	Canis lupus familiaris
eif4ebp3	Danio rerio
eif4ebp3l	Danio rerio
Eif4ebp3	Mus musculus
EIF4EBP3	Pan troglodytes
Eif4ebp3	Rattus norvegicus

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