Disease relevance of HSFY1

• These results may suggest that deletion of HSFY is involved in azoospermia or oligospermia [1].
• We propose that deletions of the testis-specific HSFY gene family may be a cause of unexplained cases of idiopathic male infertility [2].

High impact information on HSFY1

• Expression analysis of HSFY, LW-1, and mHSFYL unveiled that they are expressed predominantly in testis [1].
• Furthermore, immunhistochemistry of HSFY in testis showed that its expression is restricted to both Sertoli cells and spermatogenic cells and that it exhibits a stage-dependent translocation from the cytoplasm to the nucleus in spermatogenetic cells during spermatogenesis [1].
• LW-1 and mHSFYL have 53% and 70% homology to HSFY for amino acid sequences of their presumed DNA-binding domains, respectively [1].
• However, newly available sequence data deposited at NCBI shows that only the HSFY gene located on Yq has a long open reading frame containing a HSF-type DNA-binding domain [1].
• These data suggest that HSFY could have an important role in human spermatogenesis [3].

Biological context of HSFY1

• Two identical and functional full-length copies of HSFY map in palindrome P4 of AZFb, whereas four similar sequences mapping in two clusters in palindrome P1 of AZFc and P3 seem to represent pseudogenes [3].
• Sequences similar to few HSFY exons are also located in the short arm of chromosomes Y, X and 22 [3].
• CONCLUSION(S): Altered expression of the HSFY in the testis showing deteriorated spermatogenesis may be associated with alteration of spermatogenic cell differentiation [4].

Analytical, diagnostic and therapeutic context of HSFY1

• Immunostaining and Western blotting techniques determined the expression of HSFY [4].

References