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Gene Review

EIF3C  -  eukaryotic translation initiation factor 3...

Homo sapiens

Synonyms: EIF3CL, EIF3S8, Eukaryotic translation initiation factor 3 subunit 8, Eukaryotic translation initiation factor 3 subunit C, eIF3 p110, ...
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Disease relevance of EIF3S8


High impact information on EIF3S8

  • We show that the binding site for eIF2beta is located in a surface area containing aromatic and acidic residues (aromatic/acidic boxes), that the binding sites for eIF1 and eIF3c are located in a conserved surface region of basic residues, and that eIF4G binds eIF5-CTD at an interface overlapping with the acidic area [2].
  • We found that schwannomin was most effective for inhibiting cellular proliferation when eIF3c was highly expressed [3].
  • We identified the p110 subunit of the eukaryotic initiation factor 3 (eIF3c) as a schwannomin interacting protein [3].
  • The IF5-CTD interacts directly with the translation initiation factors eIF1, eIF2-beta, and eIF3c, thus forming together with eIF2 bound Met-tRNA(i)(Met) the MFC [4].

Other interactions of EIF3S8

  • Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c) [3].


  1. Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas. Rothe, M., Ko, Y., Albers, P., Wernert, N. Am. J. Pathol. (2000) [Pubmed]
  2. The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G. Yamamoto, Y., Singh, C.R., Marintchev, A., Hall, N.S., Hannig, E.M., Wagner, G., Asano, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c). Scoles, D.R., Yong, W.H., Qin, Y., Wawrowsky, K., Pulst, S.M. Hum. Mol. Genet. (2006) [Pubmed]
  4. The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5. Bieniossek, C., Schütz, P., Bumann, M., Limacher, A., Uson, I., Baumann, U. J. Mol. Biol. (2006) [Pubmed]
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