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Gene Review

HERC1  -  HECT and RLD domain containing E3...

Homo sapiens

Synonyms: HECT domain and RCC1-like domain-containing protein 1, p532, p619
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High impact information on HERC1

  • These observations suggest that p619 is a Brefeldin A-sensitive Golgi protein that functions as a guanine nucleotide exchange factor for ARF1 and, possibly, for members of the Rab family of proteins [1].
  • Subcellular localization studies indicate that p619 is located in the cytosol and in the Golgi apparatus [1].
  • Localization of p619 in the Golgi is altered by Brefeldin A [1].
  • TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase [2].
  • The interaction between p532 and clathrin only occurs in the cytosol and is mediated by the formation of an ATP-dependent ternary complex with the heat shock protein, Hsp70 [3].

Biological context of HERC1

  • Assignment of the human P532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization [4].
  • HERC proteins are characterized by having one or more RCC1-like domains as well as a C-terminal HECT domain in their amino acid sequences [5].
  • Six HERC genes have turned up in the human genome which encode two different sorts of polypeptides: while the small HERC proteins possess little more than the two aforementioned domains, the large ones are giant proteins with a plethora of potentially important regions [6].
  • Members of the HERC (domain homologous to E6 associated protein carboxy-terminus and RCC1 domain protein) family may function both as guanine nucleotide exchange factors and E3 ubiquitin ligases [7].

Anatomical context of HERC1


Associations of HERC1 with chemical compounds


Regulatory relationships of HERC1

  • Previously, it has been shown that the RCC1-like domain 1 (RLD1) of HERC1 stimulates guanine nucleotide dissociation on ARF1 and Rab proteins [9].
  • In this study, we have analyzed whether HERC1 may also regulate ARF6 activity [9].

Other interactions of HERC1

  • We have identified HERC1 as a TSC2-interacting protein [2].
  • Thus, using this continuous LAG gel, it is possible to simultaneously analyze giant proteins, such as HERC1 and dynein, big proteins like clathrin heavy chain and small proteins like ARF [10].

Analytical, diagnostic and therapeutic context of HERC1

  • To organize and rank learning needs, HERC staff at Schwab Rehabilitation Hospital first created a universe of all perceived learning needs, which was accomplished through interviews with each staff member [11].


  1. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. Rosa, J.L., Casaroli-Marano, R.P., Buckler, A.J., Vilaró, S., Barbacid, M. EMBO J. (1996) [Pubmed]
  2. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. Chong-Kopera, H., Inoki, K., Li, Y., Zhu, T., Garcia-Gonzalo, F.R., Rosa, J.L., Guan, K.L. J. Biol. Chem. (2006) [Pubmed]
  3. A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. Rosa, J.L., Barbacid, M. Oncogene (1997) [Pubmed]
  4. Assignment of the human P532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization. Cruz, C., Paladugu, A., Ventura, F., Bartrons, R., Aldaz, M., Rosa, J.L. Cytogenet. Cell Genet. (1999) [Pubmed]
  5. Interaction between HERC1 and M2-type pyruvate kinase. Garcia-Gonzalo, F.R., Cruz, C., Muñoz, P., Mazurek, S., Eigenbrodt, E., Ventura, F., Bartrons, R., Rosa, J.L. FEBS Lett. (2003) [Pubmed]
  6. The HERC proteins: functional and evolutionary insights. Garcia-Gonzalo, F.R., Rosa, J.L. Cell. Mol. Life Sci. (2005) [Pubmed]
  7. HERC3 binding to and regulation by ubiquitin. Cruz, C., Ventura, F., Bartrons, R., Rosa, J.L. FEBS Lett. (2001) [Pubmed]
  8. The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells. Garcia-Gonzalo, F.R., Muñoz, P., González, E., Casaroli-Marano, R.P., Vilaró, S., Bartrons, R., Ventura, F., Rosa, J.L. FEBS Lett. (2004) [Pubmed]
  9. Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins. Garcia-Gonzalo, F.R., Bartrons, R., Ventura, F., Rosa, J.L. FEBS Lett. (2005) [Pubmed]
  10. Simultaneous electrophoretic analysis of proteins of very high and low molecular weights using low-percentage acrylamide gel and a gradient SDS-PAGE gel. Casas-Terradellas, E., Garcia-Gonzalo, F.R., Hadjebi, O., Bartrons, R., Ventura, F., Rosa, J.L. Electrophoresis (2006) [Pubmed]
  11. Centralized continuing education programs: assessing interdisciplinary learning needs. Atchison, T.A., Brooks, E.T. QRB. Quality review bulletin. (1981) [Pubmed]
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