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Gene Review

CLTC  -  clathrin, heavy chain (Hc)

Homo sapiens

Synonyms: CHC, CHC17, CLH-17, CLH17, CLTCL2, ...
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Disease relevance of CLTC


High impact information on CLTC


Biological context of CLTC


Anatomical context of CLTC

  • Moreover, these results demonstrate the presence of CLTC-ALK fusions in these tumors and extend the list of diseases associated with this genetic abnormality to include classical T-cell or null ALCL, ALK+ DLBCL, and inflammatory myofibroblastic tumors [9].
  • CHC17 forms the ubiquitous clathrin-coated vesicles that mediate membrane traffic [8].
  • Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells [12].
  • CHC22 protein is upregulated during myoblast differentiation into myotubes and is expressed at high levels in muscle and at low levels in non-muscle cells, relative to CHC17 [13].
  • To investigate the role of clathrin in coated vesicle formation, a cell line with inducible expression of clathrin heavy chain (CHC) antisense RNA was produced [14].

Associations of CLTC with chemical compounds


Physical interactions of CLTC


Other interactions of CLTC

  • The interaction between ARH and clathrin was mapped to a canonical clathrin box sequence (LLDLE) in ARH and to the N-terminal domain of the clathrin heavy chain [23].
  • CHC17 is bound and regulated by LCa and LCb, whereas CHC22 does not functionally interact with either light chain [8].
  • HIP1 binds to the clathrin adaptor protein 2 (AP2) and the terminal domain of the clathrin heavy chain, predominantly through a small fragment encompassing amino acids 276-335 [24].
  • We demonstrate that clathrin binding requires a motif (LLDMD) located near the MLK2 C terminus, which is similar to "clathrin box" motifs important for binding of clathrin coat assembly and accessory proteins to the clathrin heavy chain [18].
  • We have used RNA interference to knock down the AP-2 mu2 subunit and clathrin heavy chain to undetectable levels in HeLaM cells [25].

Analytical, diagnostic and therapeutic context of CLTC


  1. ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma. De Paepe, P., Baens, M., van Krieken, H., Verhasselt, B., Stul, M., Simons, A., Poppe, B., Laureys, G., Brons, P., Vandenberghe, P., Speleman, F., Praet, M., De Wolf-Peeters, C., Marynen, P., Wlodarska, I. Blood (2003) [Pubmed]
  2. A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17)(p11.2;q23). Argani, P., Lui, M.Y., Couturier, J., Bouvier, R., Fournet, J.C., Ladanyi, M. Oncogene (2003) [Pubmed]
  3. Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome. Sirotkin, H., Morrow, B., DasGupta, R., Goldberg, R., Patanjali, S.R., Shi, G., Cannizzaro, L., Shprintzen, R., Weissman, S.M., Kucherlapati, R. Hum. Mol. Genet. (1996) [Pubmed]
  4. Clathrin gene expression is androgen regulated in the prostate. Prescott, J.L., Tindall, D.J. Endocrinology (1998) [Pubmed]
  5. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Wilde, A., Beattie, E.C., Lem, L., Riethof, D.A., Liu, S.H., Mobley, W.C., Soriano, P., Brodsky, F.M. Cell (1999) [Pubmed]
  6. Association of the AP-3 adaptor complex with clathrin. Dell'Angelica, E.C., Klumperman, J., Stoorvogel, W., Bonifacino, J.S. Science (1998) [Pubmed]
  7. Requirement of clathrin heavy chain for p53-mediated transcription. Enari, M., Ohmori, K., Kitabayashi, I., Taya, Y. Genes Dev. (2006) [Pubmed]
  8. Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Wakeham, D.E., Abi-Rached, L., Towler, M.C., Wilbur, J.D., Parham, P., Brodsky, F.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases. Gascoyne, R.D., Lamant, L., Martin-Subero, J.I., Lestou, V.S., Harris, N.L., Müller-Hermelink, H.K., Seymour, J.F., Campbell, L.J., Horsman, D.E., Auvigne, I., Espinos, E., Siebert, R., Delsol, G. Blood (2003) [Pubmed]
  10. Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter. Dodge, G.R., Kovalszky, I., McBride, O.W., Yi, H.F., Chu, M.L., Saitta, B., Stokes, D.G., Iozzo, R.V. Genomics (1991) [Pubmed]
  11. ALK-positive diffuse large B-cell lymphoma. Bubała, H., Małdyk, J., Włodarska, I., Sońta-Jakimczyk, D., Szczepański, T. Pediatric blood & cancer. (2006) [Pubmed]
  12. Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells. Hinrichsen, L., Harborth, J., Andrees, L., Weber, K., Ungewickell, E.J. J. Biol. Chem. (2003) [Pubmed]
  13. A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network. Liu, S.H., Towler, M.C., Chen, E., Chen, C.Y., Song, W., Apodaca, G., Brodsky, F.M. EMBO J. (2001) [Pubmed]
  14. Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA. Iversen, T.G., Skretting, G., van Deurs, B., Sandvig, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism. Grimmer, S., Ying, M., Wälchli, S., van Deurs, B., Sandvig, K. Traffic (2005) [Pubmed]
  16. A role for clathrin in reassembly of the Golgi apparatus. Radulescu, A.E., Siddhanta, A., Shields, D. Mol. Biol. Cell (2007) [Pubmed]
  17. Hepatitis C virus entry depends on clathrin-mediated endocytosis. Blanchard, E., Belouzard, S., Goueslain, L., Wakita, T., Dubuisson, J., Wychowski, C., Rouillé, Y. J. Virol. (2006) [Pubmed]
  18. Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking. Akbarzadeh, S., Ji, H., Frecklington, D., Marmy-Conus, N., Mok, Y.F., Bowes, L., Devereux, L., Linsenmeyer, M., Simpson, R.J., Dorow, D.S. J. Biol. Chem. (2002) [Pubmed]
  19. Hrs recruits clathrin to early endosomes. Raiborg, C., Bache, K.G., Mehlum, A., Stang, E., Stenmark, H. EMBO J. (2001) [Pubmed]
  20. The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Laporte, S.A., Oakley, R.H., Zhang, J., Holt, J.A., Ferguson, S.S., Caron, M.G., Barak, L.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  21. Clathrin box in G protein-coupled receptor kinase 2. Shiina, T., Arai, K., Tanabe, S., Yoshida, N., Haga, T., Nagao, T., Kurose, H. J. Biol. Chem. (2001) [Pubmed]
  22. Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network. Choudhury, R., Diao, A., Zhang, F., Eisenberg, E., Saint-Pol, A., Williams, C., Konstantakopoulos, A., Lucocq, J., Johannes, L., Rabouille, C., Greene, L.E., Lowe, M. Mol. Biol. Cell (2005) [Pubmed]
  23. ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. He, G., Gupta, S., Yi, M., Michaely, P., Hobbs, H.H., Cohen, J.C. J. Biol. Chem. (2002) [Pubmed]
  24. HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2. Metzler, M., Legendre-Guillemin, V., Gan, L., Chopra, V., Kwok, A., McPherson, P.S., Hayden, M.R. J. Biol. Chem. (2001) [Pubmed]
  25. Clathrin-mediated endocytosis in AP-2-depleted cells. Motley, A., Bright, N.A., Seaman, M.N., Robinson, M.S. J. Cell Biol. (2003) [Pubmed]
  26. T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. Crotzer, V.L., Mabardy, A.S., Weiss, A., Brodsky, F.M. J. Exp. Med. (2004) [Pubmed]
  27. Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes. Corvera, S. J. Biol. Chem. (1990) [Pubmed]
  28. Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin. Scheele, U., Alves, J., Frank, R., Duwel, M., Kalthoff, C., Ungewickell, E. J. Biol. Chem. (2003) [Pubmed]
  29. Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites. Brodsky, F.M. J. Cell Biol. (1985) [Pubmed]
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