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Gene Review

TGIF2LX  -  TGFB-induced factor homeobox 2-like, X-linked

Homo sapiens

Synonyms: Homeobox protein TGIF2LX, TGF-beta-induced transcription factor 2-like protein, TGFB-induced factor 2-like protein, X-linked, TGIF-like on the X, TGIFLX
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High impact information on TGIF2LX

  • While TGIF2 is ubiquitously expressed, TGIFLX is exclusively expressed in adult testis [1].
  • TGIFLX is an X-linked homeobox gene that originated by retroposition of the autosomal gene TGIF2, most likely in a common ancestor of rodents and primates [1].
  • The conservation, similarity to protein-encoding transcription factors, and specific expression in testis points to a transcriptional role for TGIFLX/Y in this tissue [2].
  • TGIFLX/Y has a 2666-bp mRNA encoded by two exons separated by a 96-bp intron [2].
  • Cloning and sequencing of TGIFLX homologs in hominoids and Old World monkeys provides evidence for an open reading frame in the eight species studied [2].

Biological context of TGIF2LX

  • Comparative DNA analysis indicates that TGIFLX originated from retrotransposition of TGIF2, located on 20q11.2-12, onto the X Chromosome. RT-PCR analysis reveals that both X- and Y-linked genes are specifically expressed in adult testis [2].

Other interactions of TGIF2LX

  • Although the physiological function of and the exact selective agent on TGIFLX and other rapidly evolving homeobox genes are unclear, the common expression pattern of these transcription factor genes led us to conjecture that the selection is related to one or more aspects of male reproduction and may contribute to speciation [1].


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