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Gene Review:

Tgif2lx1 - TGFB-induced factor homeobox 2-like, X...

Mus musculus

Synonyms: OTTMUSG00000018465, Tex1, Tgif2lx, Tgifx1

Lai, Y.L. et al., Bertolino, E. et al.

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High impact information on Tgifx1

Furthermore, the results of in situ hybridization analysis reveal that the expression of Tex1 in testis is restricted in the germ cells at spermatid stage [1].
Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis [1].
Based on these data, it is suggested that Tex1, a novel testis homeobox gene, may play a crucial role during spermatogenesis [1].
We isolated a novel homeobox gene designated Tex1 from a mouse testis cDNA library by degenerate oligonucleotide polymerase chain reaction (PCR) screening [1].
The TGIF homeobox gene encodes a homeoprotein that represses the 9-cis retinoic acid receptor-dependent transcription activation [2].

Biological context of Tgifx1

Three extra amino acid residues, AYP, are inserted between the first and second helices of the homeodomain, which makes Tex1 a TGIF subclass homeobox gene [1].

Anatomical context of Tgifx1

Tex1 expression is initiated at around day 20 of testes [1].

Analytical, diagnostic and therapeutic context of Tgifx1

Tex1 was expressed specifically in the testis as seen by both Northern blot and RT-PCR analysis [1].

References

Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis. Lai, Y.L., Li, H., Chiang, H.S., Hsieh-Li, H.M. Mech. Dev. (2002) [Pubmed]
Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation. Bertolino, E., Wildt, S., Richards, G., Clerc, R.G. Dev. Dyn. (1996) [Pubmed]

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TGIF2LX	Canis lupus familiaris
TGIF2LX	Homo sapiens
TGIF2LX	Macaca mulatta
Tgif2lx2	Mus musculus
TGIF2LX	Pan troglodytes

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