Disease relevance of TGIF2

• TGIF2 appears to be a context-independent transcriptional repressor, which can perform similar functions to TGIF and may play a role in processes, which, when disrupted by mutations in TGIF, cause holoprosencephaly [1].
• Since amplification of 20q is often observed among ovarian cancers, we determined the status of DNA copy-number and expression of TGIF2 in 14 ovarian-cancer cell lines [2].

High impact information on TGIF2

• TGIF2 interacts with histone deacetylase 1 and represses transcription [1].
• TGIF2 interacts with TGF beta-activated Smads and represses TGF beta-responsive transcription [1].
• Searching human expressed sequence tag data bases revealed the presence of clones encoding a TGIF-related protein (TGIF2), which contains two regions of high sequence identity with TGIF [1].
• While TGIF2 is ubiquitously expressed, TGIFLX is exclusively expressed in adult testis [3].
• Overexpression of TGIF2 and PTPN1 was not significant in our immortalized HOSE cell systems [4].

Biological context of TGIF2

• TGIF2 lies on chromosome 20q11.2-12 [2].
• The results suggested that TGIF2 may play an important role in the development and/or progression of some ovarian tumors through a mechanism of gene amplification [2].
• The TGIF2 product contains a putative nuclear localization signal; translocation of the protein to the nucleus was confirmed by transfection of epitope-tagged cDNA [2].
• Comparative DNA analysis indicates that TGIFLX originated from retrotransposition of TGIF2, located on 20q11.2-12, onto the X Chromosome. RT-PCR analysis reveals that both X- and Y-linked genes are specifically expressed in adult testis [5].

Other interactions of TGIF2

• Among 19 primary OCs examined, moreover, we observed amplification of TGIF2, PTPN1 and ZNF217 in five (26.3%), ten (52.6%), and twelve (63.2%) tumors, respectively [6].
• The related TGIF2 protein functions in a similar manner, but does not bind CtBP [7].
• TGIF and TGIF2 share two major blocks of similarity, encompassing the homeodomain, and a conserved carboxyl terminal repression domain [7].
• Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines [2].

References