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Chemical Compound Review

D-Allylglycine     (2S)-2-aminopent-4-enoic acid

Synonyms: L-Allylglycine, Lopac-A-7762, AG-A-08119, CHEMBL1229875, A7762_SIGMA, ...
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Disease relevance of Lopac-A-7762

  • We conclude that most of the pathological changes observed after 1.5 h of L-allylglycine induced status epilepticus, including the mitochondrial calcium "overload" are reversible [1].
  • We recently demonstrated that long-lasting photosensitivity is acquired as a result of kindling of the lateral geniculate nucleus (LGN), and that the LGN-kindled cat pretreated with D, L-allylglycine represents a useful model of epilepsy for drug studies [2].
  • Male and female rats were injected (IP) with the GABA antagonist, L-allylglycine (100, 150, 200, or 250 mg/kg), and observed for behavioral signs of five categories of seizures induced by picrotoxin: myoclonic, focal, generalized tonic extension, generalized clonic, and generalized seizures with tonic and clonic components [3].
  • Intracerebroventricular injection of L-allylglycine, D-allyglycine or D,L-allyglycine, 100 mg in 1 ml saline, did not modify the natural syndrome of photosensitive epilepsy [4].
  • In rats with chronic disruption of GABA-mediated inhibition in the dorsomedial hypothalamus (DMH), achieved by chronic microinfusion of the glutamic acid decarboxylase inhibitor L-allylglycine, sodium lactate infusions or yohimbine elicits panic-like responses (i.e., anxiety, tachycardia, hypertension, and tachypnea) [5].

High impact information on Lopac-A-7762


Biological context of Lopac-A-7762


Anatomical context of Lopac-A-7762


Associations of Lopac-A-7762 with other chemical compounds


Gene context of Lopac-A-7762


Analytical, diagnostic and therapeutic context of Lopac-A-7762


  1. Status epilepticus: the reversibility of calcium loading and acute neuronal pathological changes in the rat hippocampus. Griffiths, T., Evans, M.C., Meldrum, B.S. Neuroscience (1984) [Pubmed]
  2. Suppressive effects of L-5-hydroxytryptophan in a feline model of photosensitive epilepsy. Wada, Y., Hasegawa, H., Nakamura, M., Yamaguchi, N. Brain Res. (1991) [Pubmed]
  3. Allylglycine-induced seizures in male and female rats. Thomas, J., Yang, Y.C. Physiol. Behav. (1991) [Pubmed]
  4. Proconvulsant, convulsant and other actions of the D- and L-stereoisomers of allylglycine in the photosensitive baboon, Papio papio. Meldrum, B.S., Menini, C., Naquet, R., Laurent, H., Stutzmann, J.M. Electroencephalography and clinical neurophysiology. (1979) [Pubmed]
  5. Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus. Shekhar, A., Johnson, P.L., Sajdyk, T.J., Fitz, S.D., Keim, S.R., Kelley, P.E., Gehlert, D.R., DiMicco, J.A. J. Neurosci. (2006) [Pubmed]
  6. Mechanism for the desulfurization of L-cysteine catalyzed by the nifS gene product. Zheng, L., White, R.H., Cash, V.L., Dean, D.R. Biochemistry (1994) [Pubmed]
  7. Endogenous release of gamma-aminobutyric acid from the medial preoptic area measured by microdialysis in the anaesthetised rat. Herbison, A.E., Heavens, R.P., Dyer, R.G. J. Neurochem. (1990) [Pubmed]
  8. Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. Chapman, A.G., Westerberg, E., Premachandra, M., Meldrum, B.S. J. Neurochem. (1984) [Pubmed]
  9. Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate. Abshire, V.M., Hankins, K.D., Roehr, K.E., DiMicco, J.A. Neuropharmacology (1988) [Pubmed]
  10. Photodynamic properties of pyridoxal phosphate bound to cystathionase-gamma-lyase. Beeler, T., Churchich, J.E. Biochim. Biophys. Acta (1978) [Pubmed]
  11. Strychnine and L-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats. Sugimoto, T., Takemura, M., Okubo, J., Sakai, A. Brain Res. (1985) [Pubmed]
  12. Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions. Shekhar, A., Keim, S.R., Simon, J.R., McBride, W.J. Pharmacol. Biochem. Behav. (1996) [Pubmed]
  13. Escape behavior produced by the blockade of glutamic acid decarboxylase (GAD) in mesencephalic central gray or medial hypothalamus. Brandao, M.L., Di Scala, G., Bouchet, M.J., Schmitt, P. Pharmacol. Biochem. Behav. (1986) [Pubmed]
  14. Propofol-induced anesthesia in mice is mediated by gamma-aminobutyric acid-A and excitatory amino acid receptors. Irifune, M., Takarada, T., Shimizu, Y., Endo, C., Katayama, S., Dohi, T., Kawahara, M. Anesth. Analg. (2003) [Pubmed]
  15. Involvement of the GABAergic system on shock-induced aggressive behavior in two strains of mice. Puglisi-Allegra, S., Simler, S., Kempf, E., Mandel, P. Pharmacol. Biochem. Behav. (1981) [Pubmed]
  16. Intracellular calcium accumulation in rat hippocampus during seizures induced by bicuculline or L-allylglycine. Griffiths, T., Evans, M.C., Meldrum, B.S. Neuroscience (1983) [Pubmed]
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