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Gene Review:

STARD13 - StAR-related lipid transfer (START) domain...

Homo sapiens

Synonyms: 46H23.2, ARHGAP37, DLC-2, DLC2, Deleted in liver cancer 2 protein, ...

Ching, Y.P. et al., Leung, T.H. et al., Brand??o, M.M. et al., Vargo-Gogola, T. et al., Popescu, N.C. et al.

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Disease relevance of STARD13

The deleted in liver cancer 2 (DLC2) gene, located at chromosome 13q12.3, is a recently identified tumor suppressor gene [1].

High impact information on STARD13

In contrast, cells transfected with inactive DLC2 GAP-mutant remained unchanged in cell morphology, actin stress fiber formation, and RhoA activity [1].
DLC2 is homologous to DLC1, a previously identified tumor suppressor gene at 8p22-p21.3 frequently deleted in HCC [2].
In search of tumor suppressor genes in this region, here we have identified DLC2 (for deleted in liver cancer 2) at 13q12.3 encoding a novel Rho family GTPase-activating protein (GAP) [2].
Introduction of human DLC2 into mouse fibroblasts suppresses Ras signaling and Ras-induced cellular transformation in a GAP-dependent manner [2].
P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland [3].

Biological context of STARD13

Rho GTPase activating protein cDNA on chromosome 13q12 is the deleted in liver cancer (DLC2) gene [4].

Other interactions of STARD13

Proteins containing an Rho GTPase-activating protein (RhoGAP) domain work as molecular switches involved in the regulation of diverse cellular functions [5].

References

Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Leung, T.H., Ching, Y.P., Yam, J.W., Wong, C.M., Yau, T.O., Jin, D.Y., Ng, I.O. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. Ching, Y.P., Wong, C.M., Chan, S.F., Leung, T.H., Ng, D.C., Jin, D.Y., Ng, I.O. J. Biol. Chem. (2003) [Pubmed]
P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland. Vargo-Gogola, T., Heckman, B.M., Gunther, E.J., Chodosh, L.A., Rosen, J.M. Mol. Endocrinol. (2006) [Pubmed]
Rho GTPase activating protein cDNA on chromosome 13q12 is the deleted in liver cancer (DLC2) gene. Popescu, N.C., Durkin, M.E. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Phylogenetic Analysis of RhoGAP Domain-Containing Proteins. Brand??o, M.M., Silva-Brand??o, K.L., Costa, F.F., Saad, S.T. Genomics Proteomics Bioinformatics (2006) [Pubmed]

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