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Gene Review

RND1  -  Rho family GTPase 1

Homo sapiens

Synonyms: ARHS, RHO6, RHOS, Rho-related GTP-binding protein Rho6, Rho6, ...
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Disease relevance of RND1


High impact information on RND1


Biological context of RND1


Anatomical context of RND1


Associations of RND1 with chemical compounds


Physical interactions of RND1


Regulatory relationships of RND1

  • The process formation induced by Rnd1 was inhibited by dominant negative Rac1 [17].
  • Recruitment of active Rnd1 is sufficient to trigger signaling by Plexin-A1, even in the absence of Sema3A, and initiates cytoskeletal collapse by activating its cytoplasmic domain [24].

Other interactions of RND1

  • Further experiments show that H-Ras, Rheb, Rho6 and G alpha(i1) interact with PDE delta and that, at least for H-Ras, the intact C-terminus is required [25].
  • Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family [18].
  • Thus, the antagonism of two GTPases regulates the activity of the Sema3A receptor, and activation by Rnd1 appears to be an essential step in signaling by Plexin-A1 [24].
  • Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse [24].
  • Inhibition of Rac1, another Rho family GTPase, had a less-pronounced inhibitory effect, while blocking of Rho activity showed no discernible influence [26].

Analytical, diagnostic and therapeutic context of RND1


  1. The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis. Haddad, E., Zugaza, J.L., Louache, F., Debili, N., Crouin, C., Schwarz, K., Fischer, A., Vainchenker, W., Bertoglio, J. Blood (2001) [Pubmed]
  2. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. Ching, Y.P., Wong, C.M., Chan, S.F., Leung, T.H., Ng, D.C., Jin, D.Y., Ng, I.O. J. Biol. Chem. (2003) [Pubmed]
  3. Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Jiang, W.G., Watkins, G., Lane, J., Cunnick, G.H., Douglas-Jones, A., Mokbel, K., Mansel, R.E. Clin. Cancer Res. (2003) [Pubmed]
  4. Expression of the Rho-family GTPase gene RHOF in lymphocyte subsets and malignant lymphomas. Gouw, L.G., Reading, N.S., Jenson, S.D., Lim, M.S., Elenitoba-Johnson, K.S. Br. J. Haematol. (2005) [Pubmed]
  5. Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Ashcroft, F.J., Varro, A., Dimaline, R., Dockray, G.J. Biochem. J. (2004) [Pubmed]
  6. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Ho, H.Y., Rohatgi, R., Lebensohn, A.M., Le Ma, n.u.l.l., Li, J., Gygi, S.P., Kirschner, M.W. Cell (2004) [Pubmed]
  7. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Kim, A.S., Kakalis, L.T., Abdul-Manan, N., Liu, G.A., Rosen, M.K. Nature (2000) [Pubmed]
  8. Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway. Simon, M.N., De Virgilio, C., Souza, B., Pringle, J.R., Abo, A., Reed, S.I. Nature (1995) [Pubmed]
  9. Leukocyte transendothelial migration: orchestrating the underlying molecular machinery. Worthylake, R.A., Burridge, K. Curr. Opin. Cell Biol. (2001) [Pubmed]
  10. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Eisenmann, K.M., McCarthy, J.B., Simpson, M.A., Keely, P.J., Guan, J.L., Tachibana, K., Lim, L., Manser, E., Furcht, L.T., Iida, J. Nat. Cell Biol. (1999) [Pubmed]
  11. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. Nobes, C.D., Lauritzen, I., Mattei, M.G., Paris, S., Hall, A., Chardin, P. J. Cell Biol. (1998) [Pubmed]
  12. Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Chen, L., Liao, G., Yang, L., Campbell, K., Nakafuku, M., Kuan, C.Y., Zheng, Y. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  13. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. Oinuma, I., Katoh, H., Harada, A., Negishi, M. J. Biol. Chem. (2003) [Pubmed]
  14. Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2. Tanaka, H., Fujita, H., Katoh, H., Mori, K., Negishi, M. Biochem. J. (2002) [Pubmed]
  15. Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors. Hirotani, M., Ohoka, Y., Yamamoto, T., Nirasawa, H., Furuyama, T., Kogo, M., Matsuya, T., Inagaki, S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  16. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Katoh, H., Harada, A., Mori, K., Negishi, M. Mol. Cell. Biol. (2002) [Pubmed]
  17. Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. Aoki, J., Katoh, H., Mori, K., Negishi, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  18. Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. Vayssière, B., Zalcman, G., Mahé, Y., Mirey, G., Ligensa, T., Weidner, K.M., Chardin, P., Camonis, J. FEBS Lett. (2000) [Pubmed]
  19. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Hildebrand, J.D., Taylor, J.M., Parsons, J.T. Mol. Cell. Biol. (1996) [Pubmed]
  20. Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil. Fessler, M.B., Arndt, P.G., Frasch, S.C., Lieber, J.G., Johnson, C.A., Murphy, R.C., Nick, J.A., Bratton, D.L., Malcolm, K.C., Worthen, G.S. J. Biol. Chem. (2004) [Pubmed]
  21. Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulation. Hubchak, S.C., Runyan, C.E., Kreisberg, J.I., Schnaper, H.W. J. Am. Soc. Nephrol. (2003) [Pubmed]
  22. Chlamydiae host cell interactions revealed using DNA microarrays. Mahony, J.B. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  23. Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. Linseman, D.A., Heidenreich, K.A., Fisher, S.K. J. Biol. Chem. (2001) [Pubmed]
  24. Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse. Zanata, S.M., Hovatta, I., Rohm, B., Püschel, A.W. J. Neurosci. (2002) [Pubmed]
  25. The complex of Arl2-GTP and PDE delta: from structure to function. Hanzal-Bayer, M., Renault, L., Roversi, P., Wittinghofer, A., Hillig, R.C. EMBO J. (2002) [Pubmed]
  26. Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex. Linder, S., Heimerl, C., Fingerle, V., Aepfelbacher, M., Wilske, B. Infect. Immun. (2001) [Pubmed]
  27. Designing biosensors for Rho family proteins--deciphering the dynamics of Rho family GTPase activation in living cells. Pertz, O., Hahn, K.M. J. Cell. Sci. (2004) [Pubmed]
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