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Gene Review

ASH2L  -  ash2 (absent, small, or homeotic)-like...

Homo sapiens

Synonyms: ASH2, ASH2-like protein, ASH2L1, ASH2L2, Bre2, ...
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High impact information on ASH2L


Biological context of ASH2L

  • Through large-scale sequencing of human genomic DNA coupled with in silico gene trapping, we identified a gene (ASH2L) on chromosome 8p11.2 whose predicted product was highly homologous to ash2, characterized it, and identified its mouse counterpart [2].

Other interactions of ASH2L

  • Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes [3].
  • These findings offer insight into the molecular role of ASH2L, and by extension that of WDR5, in proper H3K4 trimethylation [3].


  1. ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Wang, J., Zhou, Y., Yin, B., Du, G., Huang, X., Li, G., Shen, Y., Yuan, J., Qiang, B. J. Mol. Med. (2001) [Pubmed]
  2. Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene. Ikegawa, S., Isomura, M., Koshizuka, Y., Nakamura, Y. Cytogenet. Cell Genet. (1999) [Pubmed]
  3. Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Steward, M.M., Lee, J.S., O'donovan, A., Wyatt, M., Bernstein, B.E., Shilatifard, A. Nat. Struct. Mol. Biol. (2006) [Pubmed]
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