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Gene Review

ash2  -  absent, small, or homeotic discs 2

Drosophila melanogaster

Synonyms: 1124/11, 291.8, 703, ASH2, Absent, small, or homeotic discs protein 2, ...
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High impact information on ash2


Biological context of ash2


Anatomical context of ash2


Associations of ash2 with chemical compounds


Regulatory relationships of ash2

  • These results suggest that ASH2 maintains active transcription by binding a producer of nuclear phosphoinositides and downregulating histone H1 hyperphosphorylation [5].

Other interactions of ash2

  • In this paper we examine the consequences of ash1 and ash2 mutations on the expression of homeotic selector genes in imaginal discs [10].
  • Together, these experiments indicate that ash2 plays a role in two processes during wing development: (1) maintaining intervein cell fate, either by activation of intervein genes or inhibition of vein differentiation genes; and (2) keeping kni in an off state in tissues beyond the L2 vein [4].

Analytical, diagnostic and therapeutic context of ash2

  • In an attempt to identify gene targets of ash2, we have performed an expression analysis by using cDNA microarrays [2].


  1. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. Roguev, A., Schaft, D., Shevchenko, A., Pijnappel, W.W., Wilm, M., Aasland, R., Stewart, A.F. EMBO J. (2001) [Pubmed]
  2. Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster. Beltran, S., Blanco, E., Serras, F., Pérez-Villamil, B., Guigó, R., Artavanis-Tsakonas, S., Corominas, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Nagy, P.L., Griesenbeck, J., Kornberg, R.D., Cleary, M.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Activation and repression activities of ash2 in Drosophila wing imaginal discs. Angulo, M., Corominas, M., Serras, F. Development (2004) [Pubmed]
  5. The direct interaction between ASH2, a Drosophila trithorax group protein, and SKTL, a nuclear phosphatidylinositol 4-phosphate 5-kinase, implies a role for phosphatidylinositol 4,5-bisphosphate in maintaining transcriptionally active chromatin. Cheng, M.K., Shearn, A. Genetics (2004) [Pubmed]
  6. Molecular genetic analysis of Drosophila ash2, a member of the trithorax group required for imaginal disc pattern formation. Adamson, A.L., Shearn, A. Genetics (1996) [Pubmed]
  7. ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Wang, J., Zhou, Y., Yin, B., Du, G., Huang, X., Li, G., Shen, Y., Yuan, J., Qiang, B. J. Mol. Med. (2001) [Pubmed]
  8. The ash-1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related. Shearn, A. Genetics (1989) [Pubmed]
  9. High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts. Roguev, A., Schaft, D., Shevchenko, A., Aasland, R., Shevchenko, A., Stewart, A.F. J. Biol. Chem. (2003) [Pubmed]
  10. Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2. LaJeunesse, D., Shearn, A. Mech. Dev. (1995) [Pubmed]
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