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Gene Review:

glpQ - glycerophosphodiester phosphodiesterase

Escherichia coli O157:H7 str. Sakai

Shang, E.S. et al., Stebeck, C.E. et al., Schwan, T.G. et al., Cameron, C.E. et al., Porcella, S.F. et al., et al.

Shang, Skare, Erdjument-Bromage, Blanco, Tempst, Miller, Lovett,

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Disease relevance of ECs3124

In studies reported here, heterologous expression of the T. pallidum glycerophosphodiester phosphodiesterase in Escherichia coli yielded a full-length, enzymatically active protein [1].
Membrane topology and cellular location of the Treponema pallidum glycerophosphodiester phosphodiesterase (GlpQ) ortholog [2].
Sequence analysis and characterization of a 40-kilodalton Borrelia hermsii glycerophosphodiester phosphodiesterase homolog [3].
DNA sequencing, subcloning, and serum adsorption experiments identified the immunoreactive protein as a homolog of GlpQ, a glycerophosphodiester phosphodiesterase identified previously in E. coli, Haemophilus influenzae, and Bacillus subtilis [4].
Serodiagnosis of Louse-Borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis [5].

High impact information on ECs3124

Nucleotide sequence analysis demonstrated the translated protein to be a homologue of glycerophosphodiester phosphodiesterase, a glycerol metabolizing enzyme previously identified in Haemophilus influenzae, Escherichia coli, Bacillus subtilis and Borrelia hermsii [6].

Analytical, diagnostic and therapeutic context of ECs3124

We report the purification, molecular cloning, and characterization of a 40-kDa glycerophosphodiester phosphodiesterase homolog from Borrelia hermsii [3].

References

Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase. Cameron, C.E., Castro, C., Lukehart, S.A., Van Voorhis, W.C. Infect. Immun. (1998) [Pubmed]
Membrane topology and cellular location of the Treponema pallidum glycerophosphodiester phosphodiesterase (GlpQ) ortholog. Shevchenko, D.V., Sellati, T.J., Cox, D.L., Shevchenko, O.V., Robinson, E.J., Radolf, J.D. Infect. Immun. (1999) [Pubmed]
Sequence analysis and characterization of a 40-kilodalton Borrelia hermsii glycerophosphodiester phosphodiesterase homolog. Shang, E.S., Skare, J.T., Erdjument-Bromage, H., Blanco, D.R., Tempst, P., Miller, J.N., Lovett, M.A. J. Bacteriol. (1997) [Pubmed]
GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis. Schwan, T.G., Schrumpf, M.E., Hinnebusch, B.J., Anderson, D.E., Konkel, M.E. J. Clin. Microbiol. (1996) [Pubmed]
Serodiagnosis of Louse-Borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis. Porcella, S.F., Raffel, S.J., Schrumpf, M.E., Schriefer, M.E., Dennis, D.T., Schwan, T.G. J. Clin. Microbiol. (2000) [Pubmed]
Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologue. Stebeck, C.E., Shaffer, J.M., Arroll, T.W., Lukehart, S.A., Van Voorhis, W.C. FEMS Microbiol. Lett. (1997) [Pubmed]

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