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Gene Review:

CAMK2N2 - calcium/calmodulin-dependent protein...

Homo sapiens

Synonyms: CAM-KIIN, CAMKIIN, CaM-KII inhibitory protein, CaM-KIIN, Calcium/calmodulin-dependent protein kinase II inhibitor 2

Zhang, J. et al., Chang, B.H. et al.

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Disease relevance of CAMK2N2

To investigate its biological functions, full-length human CaM-KIIN was overexpressed in colon adenocarcinoma LoVo cells [1].

High impact information on CAMK2N2

Colocalization of CaM-KIIN with activated CaM-KII was demonstrated in COS-7 cells transfected with green fluorescent protein fused to CaM-KIIN [2].
In COS-7 cells phosphorylation of transfected alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors by CaM-KII, but not by protein kinase C, was blocked upon cotransfection with CaM-KIIN [2].
Here we identified a novel CaMKII inhibitor protein (CaM-KIIN) from the human dendritic cell cDNA library by large-scale random sequencing [1].
Human CaM-KIIN mRNA expression was detectable in various tissues and cell lines by Northern blot and RT-PCR [1].

References

Molecular cloning and characterization of a novel calcium/calmodulin-dependent protein kinase II inhibitor from human dendritic cells. Zhang, J., Li, N., Yu, J., Zhang, W., Cao, X. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
Characterization of a calmodulin kinase II inhibitor protein in brain. Chang, B.H., Mukherji, S., Soderling, T.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]

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