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Chemical Compound Review

ampa     2-amino-3-(5-methyl-3-oxo- 1,2-oxazol-4...

Synonyms: GNF-Pf-2579, CHEMBL13378, SureCN68799, AG-G-95466, SureCN6687427, ...
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  1. Aurintricarboxylic acid prevents GLUR2 mRNA down-regulation and delayed neurodegeneration in hippocampal CA1 neurons of gerbil after global ischemia. Aronica, E.M., Gorter, J.A., Grooms, S., Kessler, J.A., Bennett, M.V., Zukin, R.S., Rosenbaum, D.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Giordano, G., White, C.C., McConnachie, L.A., Fernandez, C., Kavanagh, T.J., Costa, L.G. Mol. Pharmacol. (2006) [Pubmed]
  3. Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors. Wong, L.A., Mayer, M.L. Mol. Pharmacol. (1993) [Pubmed]
  4. Interaction between tetanus long-term potentiation and hypoxia-induced potentiation in the rat hippocampus. Lyubkin, M., Durand, D.M., Haxhiu, M.A. J. Neurophysiol. (1997) [Pubmed]
  5. Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats. Yamashita, H., Ohno, K., Amada, Y., Hattori, H., Ozawa-Funatsu, Y., Toya, T., Inami, H., Shishikura, J., Sakamoto, S., Okada, M., Yamaguchi, T. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  6. Dissociable effects of AMPA-induced lesions of the vertical limb diagonal band of Broca on performance of the 5-choice serial reaction time task and on acquisition of a conditional visual discrimination. Muir, J.L., Bussey, T.J., Everitt, B.J., Robbins, T.W. Behav. Brain Res. (1996) [Pubmed]
  7. Positive modulators of AMPA receptors as a potential treatment for schizophrenia. Danysz, W. Current opinion in investigational drugs (London, England : 2000) (2002) [Pubmed]
  8. Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates. Porrino, L.J., Daunais, J.B., Rogers, G.A., Hampson, R.E., Deadwyler, S.A. PLoS Biol. (2005) [Pubmed]
  9. Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. Mahanty, N.K., Sah, P. Nature (1998) [Pubmed]
  10. Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia. Iino, M., Goto, K., Kakegawa, W., Okado, H., Sudo, M., Ishiuchi, S., Miwa, A., Takayasu, Y., Saito, I., Tsuzuki, K., Ozawa, S. Science (2001) [Pubmed]
  11. Bidirectional control of quantal size by synaptic activity in the hippocampus. Oliet, S.H., Malenka, R.C., Nicoll, R.A. Science (1996) [Pubmed]
  12. Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Lomeli, H., Mosbacher, J., Melcher, T., Höger, T., Geiger, J.R., Kuner, T., Monyer, H., Higuchi, M., Bach, A., Seeburg, P.H. Science (1994) [Pubmed]
  13. A single packet of transmitter does not saturate postsynaptic glutamate receptors. Ishikawa, T., Sahara, Y., Takahashi, T. Neuron (2002) [Pubmed]
  14. Hippocampal CA1 lacunosum-moleculare interneurons: comparison of effects of anoxia on excitatory and inhibitory postsynaptic currents. Khazipov, R., Congar, P., Ben-Ari, Y. J. Neurophysiol. (1995) [Pubmed]
  15. LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine. Sang, C.N., Ramadan, N.M., Wallihan, R.G., Chappell, A.S., Freitag, F.G., Smith, T.R., Silberstein, S.D., Johnson, K.W., Phebus, L.A., Bleakman, D., Ornstein, P.L., Arnold, B., Tepper, S.J., Vandenhende, F. Cephalalgia : an international journal of headache. (2004) [Pubmed]
  16. Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. Cho, J., Lee, H.K. Eur. J. Pharmacol. (2004) [Pubmed]
  17. Characterization of a calmodulin kinase II inhibitor protein in brain. Chang, B.H., Mukherji, S., Soderling, T.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  18. Dynamin-dependent endocytosis of ionotropic glutamate receptors. Carroll, R.C., Beattie, E.C., Xia, H., Lüscher, C., Altschuler, Y., Nicoll, R.A., Malenka, R.C., von Zastrow, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  19. The expression of cerebellar LTD in culture is not associated with changes in AMPA-receptor kinetics, agonist affinity, or unitary conductance. Linden, D.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  20. Mechanisms governing dendritic gamma-aminobutyric acid (GABA) release in the rat olfactory bulb. Isaacson, J.S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  21. The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning. Lin, C.H., Hansen, S., Wang, Z., Storm, D.R., Tapscott, S.J., Olson, J.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  22. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Wang, L.Y., Salter, M.W., MacDonald, J.F. Science (1991) [Pubmed]
  23. Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake. Asztely, F., Erdemli, G., Kullmann, D.M. Neuron (1997) [Pubmed]
  24. Presynaptic and postsynaptic Ca(2+) and CamKII contribute to long-term potentiation at synapses between individual CA3 neurons. Lu, F.M., Hawkins, R.D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  25. Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation. Fuchs, E.C., Doheny, H., Faulkner, H., Caputi, A., Traub, R.D., Bibbig, A., Kopell, N., Whittington, M.A., Monyer, H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  26. Mu-opioid receptors modulate the stability of dendritic spines. Liao, D., Lin, H., Law, P.Y., Loh, H.H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  27. Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in xenopus oocytes. McGurk, J.F., Bennett, M.V., Zukin, R.S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  28. Subpallial origin of a population of projecting pioneer neurons during corticogenesis. Morante-Oria, J., Carleton, A., Ortino, B., Kremer, E.J., Fairén, A., Lledo, P.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  29. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Kimonides, V.G., Khatibi, N.H., Svendsen, C.N., Sofroniew, M.V., Herbert, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  30. Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac). Svenningsson, P., Tzavara, E.T., Witkin, J.M., Fienberg, A.A., Nomikos, G.G., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  31. The mechanism of action of aniracetam at synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors: indirect and direct effects on desensitization. Lawrence, J.J., Brenowitz, S., Trussell, L.O. Mol. Pharmacol. (2003) [Pubmed]
  32. Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons. Narisawa-Saito, M., Silva, A.J., Yamaguchi, T., Hayashi, T., Yamamoto, T., Nawa, H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  33. A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Ho, A., Morishita, W., Hammer, R.E., Malenka, R.C., Sudhof, T.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  34. Neuroprotective and neurodestructive functions of nitric oxide after spinal cord hemisection. Xu, M., Ng, Y.K., Leong, S.K. Exp. Neurol. (2000) [Pubmed]
  35. Brain-derived neurotrophic factor regulates the expression of AMPA receptor proteins in neocortical neurons. Narisawa-Saito, M., Carnahan, J., Araki, K., Yamaguchi, T., Nawa, H. Neuroscience (1999) [Pubmed]
  36. Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. Senda, T., Shimomura, A., Iizuka-Kogo, A. Anatomical science international / Japanese Association of Anatomists. (2005) [Pubmed]
  37. Muscarinic stimulation of synaptic activity by protein kinase C is inhibited by adenosine in cultured hippocampal neurons. Bouron, A., Reuter, H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  38. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Alto, N.M., Soderling, S.H., Hoshi, N., Langeberg, L.K., Fayos, R., Jennings, P.A., Scott, J.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  39. Brain-derived neurotrophic factor-dependent unmasking of "silent" synapses in the developing mouse barrel cortex. Itami, C., Kimura, F., Kohno, T., Matsuoka, M., Ichikawa, M., Tsumoto, T., Nakamura, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  40. Effect of intracerebral administration of NMDA and AMPA on dopamine and glutamate release in the ventral pallidum and on motor behavior. Kretschmer, B.D., Goiny, M., Herrera-Marschitz, M. J. Neurochem. (2000) [Pubmed]
  41. In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Jakowec, M.W., Yen, L., Kalb, R.G. Neuroscience (1995) [Pubmed]
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