High impact information on Clmn

• Three alternative splicing sites were identified at the 3'-side of calmin, giving rise to polymorphic protein products with or without the transmembrane domain [1].
• The calmin transcript was detected in adult testis, liver, kidney, and large intestine; the expression in testis was far stronger than that in the other tissues [1].
• Expression of calmin, a novel developmentally regulated brain protein with calponin-homology domains [2].
• Calmin mRNA and protein were detected in neurons of the hippocampus, cerebral cortex, and thalamus, Purkinje cells, and also in the choroid plexus and ependymal cells [2].

Analytical, diagnostic and therapeutic context of Clmn

• In situ hybridization and immunostaining revealed that calmin was expressed in maturing spermatogenic cells at later stages [1].

References